Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P R China.
Chem Biodivers. 2010 Dec;7(12):2809-29. doi: 10.1002/cbdv.200900211.
Diketopiperazines (DKPs), which are cyclic dipeptides, have been detected in a variety of natural resources. Recently, the interest in these compounds increased significantly because of their remarkable bioactivity. This review deals with the chemical structures, biosynthetic pathways, and biological activities of DKPs from marine microorganisms, sponges, sea stars, tunicates (ascidians), and red algae. The literature has been covered up to December 2008, and a total 124 DKPs from 104 publications have been discussed and reviewed. Some of these compounds have been found to possess various bioactivities including cytotoxicity, and antibacterial, antifungal, antifouling, plant-growth regulatory, and other activities.
二酮哌嗪（DKP）是一种环状二肽，已在多种天然资源中被检测到。由于其显著的生物活性，最近人们对这些化合物的兴趣显著增加。本综述涉及海洋微生物、海绵、海星、被囊动物（海鞘）和红藻中 DKP 的化学结构、生物合成途径和生物活性。文献综述截至 2008 年 12 月，共讨论和综述了 104 篇出版物中的 124 种 DKP。其中一些化合物已被发现具有多种生物活性，包括细胞毒性、抗菌、抗真菌、防污、植物生长调节等活性。
