Raj C T Dhanya, Palaninathan Vivekanandan, Kandaswamy Surabhi, Kumar Vimal, James Rathinam Arthur
Department of Marine Science, Bharathidasan University, Tiruchirappalli, 620024, Tamilnadu, India.
Bio-nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama, Japan.
Heliyon. 2024 Dec 11;11(1):e41132. doi: 10.1016/j.heliyon.2024.e41132. eCollection 2025 Jan 15.
Urolithiasis affects a significant portion of the global population, causing discomfort and pain. Unfortunately, effective drugs to treat this disorder are currently unavailable due to multiple mechanisms and an incomplete understanding of its causes. Consequently, drugs with multiple targets could be a safer and more effective remedy for treating urolithiasis. Moreover, the current treatment options are expensive and come with a risk of complications and stone recurrence. Therefore, an alternative treatment that can prevent stone recurrence and reduce associated symptoms is necessary. Seaweeds are a rich source of beneficial metabolites, like antioxidants, anti-inflammatory, analgesic, and enzyme-inhibitory properties. Advances in nanotechnology hold great promise for improving the therapeutic potential of these metabolites. However, the use of nanoparticles for treating urolithiasis has yet to be explored well, and only a few reports exist on the use of terrestrial plant-based nanoparticles. This review examines the therapeutic properties of seaweed bioactive compounds and their possible applications in treating urolithiasis. We propose that seaweeds could be an excellent source of essential dietary minerals and other bioactive compounds with multiple targets to treat renal calculus naturally. Additionally, the review highlights the potential of nanomedicine in treating urolithiasis, proposing seaweed-based nanoparticles as a promising treatment option.
尿石症影响着全球相当一部分人口，会导致不适和疼痛。不幸的是，由于多种机制以及对其病因的不完全了解，目前尚无有效的药物来治疗这种疾病。因此，具有多种靶点的药物可能是治疗尿石症更安全、更有效的疗法。此外，目前的治疗选择昂贵，且存在并发症和结石复发的风险。因此，需要一种能够预防结石复发并减轻相关症状的替代治疗方法。海藻富含有益的代谢产物，如具有抗氧化、抗炎、镇痛和酶抑制特性。纳米技术的进展有望提高这些代谢产物的治疗潜力。然而，纳米颗粒在治疗尿石症方面的应用尚未得到充分探索，关于使用基于陆生植物的纳米颗粒的报道也很少。本综述探讨了海藻生物活性化合物的治疗特性及其在治疗尿石症中的可能应用。我们认为，海藻可能是必需膳食矿物质和其他具有多种靶点的生物活性化合物的优质来源，可自然地治疗肾结石。此外，该综述强调了纳米医学在治疗尿石症方面的潜力，提出基于海藻的纳米颗粒是一种有前景的治疗选择。
