Huang Ri-Ming, Yi Xiang-Xi, Zhou Yuying, Su Xiangdong, Peng Yan, Gao Cheng-Hai
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China.
Mar Drugs. 2014 Dec 19;12(12):6213-35. doi: 10.3390/md12126213.
2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.
2,5-二酮哌嗪（2,5-DKPs）是一类重要的结构多样的环状二肽，具有显著的生物学特性。这些2,5-DKPs已从包括海洋生物在内的多种自然资源中获得。由于这类化合物的数量不断增加且具有生物学重要性，本综述涵盖了2009年至2014年上半年报道的90种源自海洋的2,5-DKPs。该综述将聚焦于这些化合物的结构表征、生物学特性及推测的生物合成过程。
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