从 Cayratia japonica (Thunb.) Gagn. 中分离得到的两种新的白藜芦醇四聚体，对脂肪酸合酶具有很强的抑制活性和抗氧化活性。
Two new resveratrol tetramers isolated from Cayratia japonica (Thunb.) Gagn. with strong inhibitory activity on fatty acid synthase and antioxidant activity.
机构信息
Institute of Microbiology, Chinese Academy of Sciences, Beijing, P R China.
出版信息
Chem Biodivers. 2010 Dec;7(12):2931-40. doi: 10.1002/cbdv.200900394.
Two new resveratrol tetramers, cajyphenol A (1) and cajyphenol B (2), together with two known resveratrol dimers, quadrangularin A (3) and pallidol (4), and resveratrol (5) were isolated from the stems of Cayratia japonica (Thunb.) Gagn. Their structures were established by means of NMR (¹H,¹H-COSY, ¹H, ¹³C-HSQC, HMBC, and NOESY) and ESI-MS analyses. Compounds 1-5 showed fast-binding inhibitory activities on fatty acid synthase with the IC₅₀ values of 1.63±0.02, 1.49±0.03, 7.50±0.01, 11.1±0.01, and 10.2±0.01 μM, respectively. Compounds 1-5 also exhibited antioxidant activities in the ORAC assay.
从青藤（Cayratia japonica（Thunb.）Gagn.）的茎中分离得到了两个新的白藜芦醇四聚体，即 Cajyphenol A（1）和 Cajyphenol B（2），以及两个已知的白藜芦醇二聚体，即 quadrangularin A（3）和 pallidol（4）和白藜芦醇（5）。通过 NMR（¹H、¹H-COSY、¹H、¹³C-HSQC、HMBC 和 NOESY）和 ESI-MS 分析确定了它们的结构。化合物 1-5 对脂肪酸合酶表现出快速结合抑制活性，其 IC₅₀ 值分别为 1.63±0.02、1.49±0.03、7.50±0.01、11.1±0.01 和 10.2±0.01 μM。化合物 1-5 在 ORAC 测定中也表现出抗氧化活性。
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