橄榄体脑桥小脑萎缩患者脑干听觉诱发电位及其与脑桥体积相关性的研究
[Study of brainstem auditory evoked potentials and its correlation with pontine volume in olivopontocerebellar atrophy].
作者信息
Mao Shan-Ying, Huang Jian-Zheng, Ding Mei-Ping
机构信息
Department of Neurology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Aug;23(3):324-7.
AIM
To investigate the change of latency and interpeak latency of each component of BAEP (brainstem auditory evoked potential, BAEP) and its correlation with PV/PFV (pontine volume/posterior fossa volume, PV/PFV) ratio in OPCA (olivopontocerebellar atrophy, OPCA).
METHODS
We used Keypoint EMG/EP to determine waves I PL (peak latency, PL), III PL, V PL and I - III IPL (interpeak latency, IPL), III - V IPL, I - V IPL and used 1.5TMR 3D volume rendering software to determine PV (pontine volume, PV), CV(cerebellar volume, CV) and PFV (posterior fossa volume,PFV). Then calculated PV/PFV ratio, CV/PFV ratio and PV/ CV ratio in OPCA group and control group.
RESULTS
Compared with control group, in OPCA group wave IIII PL, I - III IPL were significantly elongated (P < 0.05), III - V IPL was significantly shorten (P < 0.05), PV/PFV ratio was significantly decreased (P < 0.01); there was a positive correlation between III-V IPL and PV/PFV ratio (r = 0.83, P < 0.01).
CONCLUSION
In patients with OPCA, III PL, I - III IPL of BAEP were elongated and III - V IPL of BAEP was shorten. III - V IPL became shorter when the volume of pontine decreased.
目的
探讨橄榄脑桥小脑萎缩（OPCA）患者脑干听觉诱发电位（BAEP）各波潜伏期及峰间潜伏期的变化及其与脑桥体积/后颅窝体积（PV/PFV）比值的相关性。
方法
采用Keypoint肌电图/诱发电位仪测定波I峰潜伏期（PL）、III PL、V PL及I-III峰间潜伏期（IPL）、III-V IPL、I-V IPL，并使用1.5T磁共振3D容积成像软件测定脑桥体积（PV）、小脑体积（CV）和后颅窝体积（PFV）。然后计算OPCA组和对照组的PV/PFV比值、CV/PFV比值和PV/CV比值。
结果
与对照组相比，OPCA组波III PL、I-III IPL明显延长（P<0.05），III-V IPL明显缩短（P<0.05），PV/PFV比值明显降低（P<0.01）；III-V IPL与PV/PFV比值呈正相关（r=0.83，P<0.01）。
结论
OPCA患者BAEP的III PL、I-III IPL延长，III-V IPL缩短。脑桥体积减小时，III-V IPL变短。
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