Tokutake T, Hayashi R, Hanyu N
Department of Neurology, Nagano Red Cross Hospital, Japan.
Electroencephalogr Clin Neurophysiol. 1995 Jul;95(1):42-6. doi: 10.1016/0013-4694(95)00036-x.
Auditory brain-stem responses (ABRs) and magnetic resonance imaging (MRI) findings were investigated in 10 patients with olivo-ponto-cerebellar atrophy (OPCA: Dejerine-Thomas type) and in 5 patients with Holmes-type cerebello-olivary degeneration. In patients with OPCA, (1) the III-V interpeak latency (IPL) was shortened significantly (P < 0.05) as compared with normal subjects when the decrease in longitudinal distance of the pons was within 20% of that of normal controls, (2) the I-III IPL was elongated (P < 0.05), the III-V IPL was shortened (P < 0.01), and the amplitude of the V wave was reduced (P < 0.05) when the decrease in longitudinal distance of the pons was more than 20% of that of normal controls. Patients with Holmes-type degeneration showed no significant difference in any component of ABRs or in the size of any part of the brain-stem, as compared with normal subjects. We conclude that abnormalities in the I-III IPL or the III-V IPL in patients with OPCA were produced by changes in the volume conduction in the pons and midbrain. This study also suggests that differences of IPL appear between OPCA and Holmes-type degeneration.
对10例橄榄脑桥小脑萎缩（OPCA：Dejerine-Thomas型）患者和5例Holmes型小脑橄榄变性患者的听觉脑干反应（ABR）和磁共振成像（MRI）结果进行了研究。在OPCA患者中，（1）当脑桥纵向距离的减小在正常对照的20%以内时，与正常受试者相比，Ⅲ-Ⅴ峰间潜伏期（IPL）显著缩短（P<0.05）；（2）当脑桥纵向距离的减小超过正常对照的20%时，Ⅰ-Ⅲ IPL延长（P<0.05），Ⅲ-Ⅴ IPL缩短（P<0.01），Ⅴ波振幅降低（P<0.05）。与正常受试者相比，Holmes型变性患者的ABR任何成分或脑干任何部位的大小均无显著差异。我们得出结论，OPCA患者Ⅰ-Ⅲ IPL或Ⅲ-Ⅴ IPL的异常是由脑桥和中脑容积传导的变化引起的。本研究还表明，OPCA和Holmes型变性之间存在IPL差异。
