Department of Molecular Biology and Microbiology, Tufts University School of Medicine and Howard Hughes Medical Institute, Boston, MA 02111, USA.
Expert Rev Vaccines. 2011 Jan;10(1):79-94. doi: 10.1586/erv.10.150.
The ability of Vibrio cholerae to persist in bodies of water will continue to confound our ability to eradicate cholera through improvements to infrastructure, and thus cholera vaccines are needed. We aim for an inexpensive vaccine that can provide long-lasting protection from all epidemic cholera infections, currently caused by O1 or O139 serogroups. Recent insights into correlates of protection, epidemiology and pathogenesis may help us design improved vaccines. This notwithstanding, we have come to appreciate that even marginally protective vaccines, such as oral whole-cell killed vaccines, if widely distributed, can provide significant protection, owing to herd immunity. Further efforts are still required to provide more effective protection of young children.
霍乱弧菌在水体中持续存在的能力将继续困扰我们通过改善基础设施来根除霍乱的能力，因此需要霍乱疫苗。我们的目标是开发一种廉价的疫苗，能够为所有人提供长效保护免受目前由 O1 或 O139 血清群引起的流行霍乱感染。最近对保护相关性、流行病学和发病机制的深入了解可能有助于我们设计改良的疫苗。尽管如此，我们已经意识到，即使是保护效果稍差的疫苗，如口服全细胞灭活疫苗，如果广泛分发，也可以通过群体免疫提供显著的保护。仍然需要进一步努力，为幼儿提供更有效的保护。
