Department of Digestive Diseases, Rush University Medical Center, 1725 West Harrison Street, Suite 207, Chicago, IL 60612-3824, USA.
Expert Rev Clin Immunol. 2011 Jan;7(1):29-36. doi: 10.1586/eci.10.83.
Inflammatory bowel disease (IBD) is a waxing and waning disease characterized by diarrhea, abdominal pain and weight loss. Recently, there has been an increased interest in the roles that sleep, circadian rhythms and melatonin could have as regulators of inflammation in the Gl tract. Advances in our understanding of the molecular machinery of the circadian clock, and the discovery of clock genes in the GI tract are opening up new avenues of research for a role of sleep in IBD. Altering circadian rhythm significantly worsens the development of colitis in animal models, and preliminary human studies have shown that patients with IBD are at increased risk for altered sleep patterns. Further research is needed to clarify the role of disturbances in IBD.
炎症性肠病（IBD）是一种时好时坏的疾病，其特征是腹泻、腹痛和体重减轻。最近，人们对睡眠、昼夜节律和褪黑素在胃肠道炎症调节中的作用越来越感兴趣。我们对昼夜节律分子机制的理解的进步，以及在胃肠道中发现的时钟基因，为睡眠在 IBD 中的作用开辟了新的研究途径。昼夜节律的显著改变会显著加重动物模型中结肠炎的发展，初步的人类研究表明，IBD 患者发生睡眠模式改变的风险增加。需要进一步的研究来阐明 IBD 中紊乱的作用。
