Schmitt H, Laubie M, Poignant J C, Krikorian A, Evrard Y, Freyria J L, Arnaud F
Sem Hop. 1978 Mar;54(5-8):325-34.
Evidence has been found for the view that piribedil stimulates peripheral and central dopamine receptors. Piribedil stimulates the nigro-striatal pathway and has been shown to be an effective antiparkinsonian agent. The stimulation of dopamine receptors in the meso-limbic and/or meso-cortical pathways lead to propose its use in the treatment of affective disorders (maia and depression). Piribedil stimulates dopamine receptors located in the tubero-infundibular pathway and reduces the secretion of prolactine, producing ablactation ; it increases the secretion of STH. Recent studies suggest that the peripheral effects of piribedil, mainly the increases in femoral and cerebral blood flows are also due to stimulation of peripheral dopamine receptors.
吡贝地尔可刺激外周和中枢多巴胺受体。吡贝地尔刺激黑质纹状体通路，已被证明是一种有效的抗帕金森病药物。中脑边缘和/或中脑皮质通路中多巴胺受体的刺激促使人们提出将其用于治疗情感障碍（躁狂和抑郁）。吡贝地尔刺激位于结节漏斗通路的多巴胺受体，减少催乳素分泌，产生回奶作用；它还增加生长激素的分泌。最近的研究表明，吡贝地尔的外周作用，主要是股血流和脑血流的增加，也是由于外周多巴胺受体的刺激所致。
