Ziegler M, Georgiadis G, Elghozi J L
Arch Mal Coeur Vaiss. 1984 Oct;77(11):1186-90.
Ten normotensive patients including 5 parkinsonian and 5 dystonic patients received 3 mg piribedil intravenously over a 15 min period. This dopamine receptor agonist rapidly induced a fall in blood pressure together with a simultaneous reduction in heart rate and temperature. No change was observed when patients (four) were pretreated with a dopamine receptor blocking agent, haloperidol. It is concluded that acute dopamine receptor stimulation leads to a decrease in blood pressure. The hypotension could be centrally-mediated since the hypothermia, considered to be central in origin, parallels the blood pressure and heart rate changes.
10名血压正常的患者（包括5名帕金森病患者和5名肌张力障碍患者）在15分钟内静脉注射了3毫克吡贝地尔。这种多巴胺受体激动剂迅速导致血压下降，同时心率和体温也降低。当患者（4名）用多巴胺受体阻断剂氟哌啶醇预处理时，未观察到变化。得出的结论是，急性多巴胺受体刺激会导致血压下降。这种低血压可能是由中枢介导的，因为被认为起源于中枢的体温过低与血压和心率变化平行。
