Ferrús A, Llamazares S, de la Pompa J L, Tanouye M A, Pongs O
Instituto Cajal, CSIC, Madrid, Spain.
Genetics. 1990 Jun;125(2):383-98. doi: 10.1093/genetics/125.2.383.
The Shaker complex (ShC) spans over 350 kb in the 16F region of the X chromosome. It can be dissected by means of aneuploids into three main sections: the maternal effect (ME), the viable (V) and the haplolethal (HL) regions. The mutational analysis of ShC shows a high density of antimorphic mutations among 12 lethal complementation groups in addition to 14 viable alleles. The complex is the structural locus of a family of potassium channels as well as a number of functions relevant to the biology of the nervous system. The constituents of ShC seem to be linked by functional relationships in view of the similarity of the phenotypes, antimorphic nature of their mutations and the behavior in transheterozygotes. We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex.
震颤复合体（ShC）位于X染色体16F区域，跨度超过350 kb。它可通过非整倍体分为三个主要部分：母体效应（ME）、存活（V）和半致死（HL）区域。ShC的突变分析表明，除了14个存活等位基因外，在12个致死互补组中存在高密度的反效突变。该复合体是一个钾通道家族的结构位点，以及许多与神经系统生物学相关的功能。鉴于其表型的相似性、突变的反效性质以及反式杂合子中的行为，ShC的组成部分似乎通过功能关系相互联系。我们讨论了ShC的遗传组织与钾电流的功能偶联以及该复合体中编码的其他功能之间的关系。
