黑腹果蝇“摇椅”基因复合体的遗传分析
Genetic analysis of the Shaker gene complex of Drosophila melanogaster.
作者信息
Ferrús A, Llamazares S, de la Pompa J L, Tanouye M A, Pongs O
机构信息
Instituto Cajal, CSIC, Madrid, Spain.
出版信息
Genetics. 1990 Jun;125(2):383-98. doi: 10.1093/genetics/125.2.383.
Abstract
The Shaker complex (ShC) spans over 350 kb in the 16F region of the X chromosome. It can be dissected by means of aneuploids into three main sections: the maternal effect (ME), the viable (V) and the haplolethal (HL) regions. The mutational analysis of ShC shows a high density of antimorphic mutations among 12 lethal complementation groups in addition to 14 viable alleles. The complex is the structural locus of a family of potassium channels as well as a number of functions relevant to the biology of the nervous system. The constituents of ShC seem to be linked by functional relationships in view of the similarity of the phenotypes, antimorphic nature of their mutations and the behavior in transheterozygotes. We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex.
摘要
震颤复合体（ShC）位于X染色体16F区域，跨度超过350 kb。它可通过非整倍体分为三个主要部分：母体效应（ME）、存活（V）和半致死（HL）区域。ShC的突变分析表明，除了14个存活等位基因外，在12个致死互补组中存在高密度的反效突变。该复合体是一个钾通道家族的结构位点，以及许多与神经系统生物学相关的功能。鉴于其表型的相似性、突变的反效性质以及反式杂合子中的行为，ShC的组成部分似乎通过功能关系相互联系。我们讨论了ShC的遗传组织与钾电流的功能偶联以及该复合体中编码的其他功能之间的关系。
相似文献
1
Genetic analysis of the Shaker gene complex of Drosophila melanogaster.黑腹果蝇“摇椅”基因复合体的遗传分析
Genetics. 1990 Jun;125(2):383-98. doi: 10.1093/genetics/125.2.383.
2
Functional relationships between genes of the Shaker gene complex of Drosophila.果蝇震颤基因复合体基因之间的功能关系。
Mol Gen Genet. 1994 Jul 25;244(2):197-204. doi: 10.1007/BF00283523.
3
Functional interactions between the gene tetanic and the Shaker gene complex of Drosophila.
Mol Gen Genet. 1994 Jul 25;244(2):205-15. doi: 10.1007/BF00283524.
4
The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.果蝇16F基因簇的单倍体致死区域：结构与功能
Genetics. 1999 Jan;151(1):163-75. doi: 10.1093/genetics/151.1.163.
5
Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila.肌钙蛋白I在果蝇的震颤基因复合体的单倍体致死区域编码。
Genes Dev. 1991 Jan;5(1):132-40. doi: 10.1101/gad.5.1.132.
6
Molecular characterization of eag: a gene affecting potassium channels in Drosophila melanogaster.eag的分子特征：一个影响黑腹果蝇钾通道的基因。
Genetics. 1991 Mar;127(3):497-505. doi: 10.1093/genetics/127.3.497.
7
Reduced sleep in Drosophila Shaker mutants.果蝇Shaker突变体的睡眠减少。
Nature. 2005 Apr 28;434(7037):1087-92. doi: 10.1038/nature03486.
8
A voltage-clamp analysis of gene-dosage effects of the Shaker locus on larval muscle potassium currents in Drosophila.果蝇中，对摇蚊基因座对幼虫肌肉钾电流的基因剂量效应进行的电压钳分析。
J Neurosci. 1990 Apr;10(4):1357-71. doi: 10.1523/JNEUROSCI.10-04-01357.1990.
9
The shaker and shaking-B genes specify elements in the processing of gustatory information in Drosophila melanogaster.“摇翅者”基因和“摇翅 -B”基因决定了黑腹果蝇味觉信息处理过程中的一些要素。
J Exp Biol. 1991 May;157:161-81. doi: 10.1242/jeb.157.1.161.
10
Gene dosage and complementation analysis of the Shaker locus in Drosophila.果蝇中震颤基因座的基因剂量与互补分析
J Neurosci. 1987 May;7(5):1307-17. doi: 10.1523/JNEUROSCI.07-05-01307.1987.
引用本文的文献
1
The role of Evi/Wntless in exporting Wnt proteins.Evi/Wntless 在 Wnt 蛋白输出中的作用。
Development. 2023 Feb 15;150(3). doi: 10.1242/dev.201352. Epub 2023 Feb 10.
2
The haplolethality paradox of the wupA gene in Drosophila.果蝇 wupA 基因的单体致死悖论。
PLoS Genet. 2021 Mar 19;17(3):e1009108. doi: 10.1371/journal.pgen.1009108. eCollection 2021 Mar.
3
Troponin-I enhances and is required for oncogenic overgrowth.肌钙蛋白I增强致癌性过度生长并为其所需。
Oncotarget. 2016 Aug 16;7(33):52631-52642. doi: 10.18632/oncotarget.10616.
4
A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly.果蝇肌钙蛋白I中的顺式调控突变揭示了肌肉组装过程中结构蛋白正确化学计量的重要性。
Genetics. 2015 May;200(1):149-65. doi: 10.1534/genetics.115.175604. Epub 2015 Mar 5.
5
Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.果蝇的转录衔接子ADA3对于组蛋白修饰、位置效应斑驳及转录是必需的。
Mol Cell Biol. 2008 Jan;28(1):376-85. doi: 10.1128/MCB.01307-07. Epub 2007 Oct 29.
6
Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.阿里阿德涅-1：一个重要的果蝇基因在发育过程中是必需的，并定义了一个新的保守的环状结构域蛋白家族。
Genetics. 2000 Jul;155(3):1231-44. doi: 10.1093/genetics/155.3.1231.
7
The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.果蝇16F基因簇的单倍体致死区域：结构与功能
Genetics. 1999 Jan;151(1):163-75. doi: 10.1093/genetics/151.1.163.
8
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.果蝇的无翅基因编码一种能激活JAK信号通路的分泌蛋白。
Genes Dev. 1998 Oct 15;12(20):3252-63. doi: 10.1101/gad.12.20.3252.
9
scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein.斯库利基因是果蝇的一个必需基因，与哺乳动物线粒体II型L-3-羟基酰基辅酶A脱氢酶/淀粉样β肽结合蛋白同源。
J Cell Biol. 1998 May 18;141(4):1009-17. doi: 10.1083/jcb.141.4.1009.
10
Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.利用一种简单高效的反向遗传学方法分离人类神经纤维瘤病2型和酵母CDC42基因的果蝇同源基因中的突变。
Genetics. 1997 May;146(1):245-52. doi: 10.1093/genetics/146.1.245.
本文引用的文献
1
Mutational Events in the Triplo- and Haplo-Lethal Region (83de) of the DROSOPHILA MELANOGASTER Genome.果蝇基因组三倍体和半倍体致死区（83de）的突变事件。
Genetics. 1980 Jun;95(2):355-66. doi: 10.1093/genetics/95.2.355.
2
Abnormal action potentials associated with the Shaker complex locus of Drosophila.与果蝇 Shaker 复合物基因座相关的异常动作电位。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6548-52. doi: 10.1073/pnas.78.10.6548.
3
Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na channel.果蝇 Shaker 复合体母性效应区的分子组织：具有脊椎动物 Na 通道同源性的 I(A)通道转录本的特性。
EMBO J. 1987 Nov;6(11):3419-29. doi: 10.1002/j.1460-2075.1987.tb02665.x.
4
An analysis of the mutagenic action of formaldehyde-food. I. Sensitivity of Drosophila germ cells.甲醛食品的诱变作用分析。I. 果蝇生殖细胞的敏感性。
Z Indukt Abstamm Vererbungsl. 1953;85(4):479-504. doi: 10.1007/BF00308298.
5
The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning.果蝇突变体破伤风与一个包括钾离子通道结构基因座的基因复合体相互作用，并表现出磷酸化改变和学习能力变化。
Eur J Neurosci. 1989 Jul;1(4):367-373. doi: 10.1111/j.1460-9568.1989.tb00801.x.
6
A combined genetic and mosaic approach to the study of oogenesis in Drosophila.一种结合遗传学和嵌合体方法对果蝇卵子发生进行的研究。
Basic Life Sci. 1980;16:85-94. doi: 10.1007/978-1-4684-7968-3_7.
7
The morphology of the cervical giant fiber neuron of Drosophila.果蝇颈部巨大纤维神经元的形态学。
Brain Res. 1981 Sep 28;221(2):213-7. doi: 10.1016/0006-8993(81)90772-1.
8
Ion currents and membrane domains in the cleaving Xenopus egg.非洲爪蟾卵裂过程中的离子电流与膜结构域
J Cell Biol. 1983 Dec;97(6):1753-61. doi: 10.1083/jcb.97.6.1753.
9
Associative conditioning of single sensory neurons suggests a cellular mechanism for learning.单个感觉神经元的联合条件作用表明了一种学习的细胞机制。
Science. 1983 Jan 28;219(4583):405-8. doi: 10.1126/science.6294834.
10
Molecular biology of learning: modulation of transmitter release.学习的分子生物学：神经递质释放的调节
Science. 1982 Oct 29;218(4571):433-43. doi: 10.1126/science.6289442.
Zotero 插件