Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany.
Eur J Cell Biol. 2011 Apr;90(4):356-64. doi: 10.1016/j.ejcb.2010.10.005. Epub 2010 Dec 16.
We collected as much information as possible on new lamin genes and their flanking genes. The number of lamin genes varies from 1 to 4 depending more or less on the phylogenetic position of the species. Strong genome drift is recognised by fewer and unusually placed introns and a change in flanking genes. This applies to the nematode Caenorhabditis elegans, the insect Drosophila melanogaster, the urochordate Ciona intestinalis, the annelid Capitella teleta and the planaria Schmidtea mediterranea. In contrast stable genomes show astonishing conservation of the flanking genes. These are identical in the sea anemone Nematostella vectensis and the cephalochordate Branchiostoma floridae lamin B1 gene. Even in the lamin B1 genes from Xenopus tropicalis and man one of the flanking genes is conserved. Finally our analysis forms the basis for a molecular analysis of metazoan phylogeny.
我们收集了尽可能多的关于新核纤层蛋白基因及其侧翼基因的信息。核纤层蛋白基因的数量从 1 个到 4 个不等，这或多或少取决于物种的系统发育位置。强烈的基因组漂移表现在较少的、位置异常的内含子和侧翼基因的变化。这适用于线虫秀丽隐杆线虫、昆虫黑腹果蝇、尾索动物文昌鱼、环节动物帽贝和涡虫。相比之下，稳定的基因组显示出侧翼基因惊人的保守性。在海葵 Nematostella vectensis 和头索动物文昌鱼的 lamin B1 基因中，这些侧翼基因是相同的。甚至在 Xenopus tropicalis 和人类的 lamin B1 基因中，一个侧翼基因也被保守下来。最后，我们的分析为后生动物系统发育的分子分析奠定了基础。
