Department of Integrated Biomedical Science and Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheon-an 31151, Korea.
Cells. 2020 Mar 14;9(3):718. doi: 10.3390/cells9030718.
Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the mechanism by which the nuclear lamina regulates inflammation is largely unknown. Recent studies have suggested that the nuclear lamina regulates both organization of the three-dimensional chromatin structure at the nuclear periphery and global gene expression, such as the expression of inflammatory response genes. Here, we discuss the current updates in the research on nuclear lamina alteration, activation of inflammation, and nuclear reorganization in models of cellular senescence and organismal aging.
衰老是组织功能和完整性逐渐丧失的特征。炎症反应的激活加速了细胞和组织的恶化。许多研究表明，核层成分的改变与体内和体外的炎症有关。然而，核层调节炎症的机制在很大程度上是未知的。最近的研究表明，核层调节核周三维染色质结构的组织和全局基因表达，如炎症反应基因的表达。在这里，我们讨论了细胞衰老和机体老化模型中核层改变、炎症激活和核重排的研究最新进展。
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