Department of Oral and Plastic Maxillofacial Surgery, Ruhr-University, Bochum, Germany.
Int J Oral Maxillofac Surg. 2011 Mar;40(3):285-91. doi: 10.1016/j.ijom.2010.11.006. Epub 2010 Dec 15.
Bisphosphonates (BPs) are widely used as bone-stabilizers, but side effects of BP therapy include bisphosphonate-related osteonecrosis of the jaw (BRONJ), which is resistant to therapy. The aim of this study was to evaluate the outcome of maxillary BRONJ involving sinusitis maxillaris. 21 patients presenting with maxillary BRONJ, from 2005 to 2008, were included in the study. In 18 cases BP had been administered for carcinoma and in 3 cases for osteoporosis, with an average exposure time of 47.4 months. 12 patients spontaneously developed BRONJ. The 10 patients diagnosed with stage III BRONJ presented with concomitant sinusitis maxillaris. Despite treatment, there were six recurrences of BRONJ, four of them with additional sinusitis maxillaris. Whether BRONJ occurred spontaneously or after extraction there was no difference in the outcome. Patients with advanced maxillary BRONJ often suffer from sinusitis maxillaris, both of which are frequently resistant to therapy.
双膦酸盐（BPs）被广泛用作骨稳定剂，但 BP 治疗的副作用包括双膦酸盐相关性下颌骨坏死（BRONJ），其对治疗有抵抗力。本研究旨在评估上颌 BRONJ 伴上颌窦炎的治疗效果。 2005 年至 2008 年间，共纳入 21 例上颌 BRONJ 患者。18 例因癌症接受 BP 治疗，3 例因骨质疏松症接受 BP 治疗，平均暴露时间为 47.4 个月。12 例患者自发性发生 BRONJ。10 例诊断为 III 期 BRONJ 的患者同时伴有上颌窦炎。尽管进行了治疗，但仍有 6 例 BRONJ 复发，其中 4 例伴有上颌窦炎。BRONJ 是自发性发生还是拔牙后发生，其结果无差异。患有晚期上颌 BRONJ 的患者常患有上颌窦炎，两者均常对治疗有抵抗力。
