Kuroishi T, Tominaga S, Morimoto T, Tashiro H, Itoh S, Watanabe H, Fukuda M, Ota J, Horino T, Ishida T
Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya.
Jpn J Cancer Res. 1990 May;81(5):454-62. doi: 10.1111/j.1349-7006.1990.tb02591.x.
To investigate the relationship between the tumor growth rate of the primary breast cancer and its prognosis, records for 122 breast cancer patients in 9 hospitals in Japan were retrospectively reviewed. These records contained at least two measurements of the same tumor mass in the breast. So the growth rate was estimated from these measurements taken at different points in time. The doubling time of the breast tumors showed an approximately log-normal distribution. The geometric mean of doubling times for all cases was 174 days. The solid-tubular histologic type of carcinoma had the shortest geometric mean of doubling time (126 days), the scirrhous carcinoma had the second shortest one (205 days), and the papillotubular carcinoma had the longest one (252 days). The patients with shorter doubling time of tumor tended to have a poorer prognosis. The Cox multiple regression analysis showed that the tumor growth rate was related significantly with survival, after adjusting for other covariates such as clinical stage, lymph node metastasis, age of patient, histological type, and year of treatment.
为了研究原发性乳腺癌的肿瘤生长速率与其预后之间的关系，我们对日本9家医院的122例乳腺癌患者的记录进行了回顾性分析。这些记录包含对乳房中同一肿瘤块至少两次的测量数据。因此，肿瘤生长速率是根据在不同时间点进行的这些测量数据估算得出的。乳腺肿瘤的倍增时间呈近似对数正态分布。所有病例的倍增时间几何平均值为174天。实体-管状组织学类型的癌倍增时间几何平均值最短（126天），硬癌次之（205天），乳头管状癌最长（252天）。肿瘤倍增时间较短的患者往往预后较差。Cox多因素回归分析显示，在对临床分期、淋巴结转移、患者年龄、组织学类型和治疗年份等其他协变量进行校正后，肿瘤生长速率与生存率显著相关。
