邻苯基苯酚钠的尿代谢产物对雌性大鼠膀胱尿路上皮的损伤及肿瘤引发作用
Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
作者信息
Hasegawa R, Furukawa F, Toyoda K, Sato H, Takahashi M, Hayashi Y
机构信息
Division of Pathology, National Institute of Hygienic Sciences, Tokyo.
出版信息
Jpn J Cancer Res. 1990 May;81(5):483-8. doi: 10.1111/j.1349-7006.1990.tb02595.x.
Intravesical instillation of 2-phenyl-1,4-benzoquinone (PBQ), a metabolite of sodium o-phenylphenate (Na-OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor-initiating activity was observed with either Na-OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na-OPP urinary bladder carcinogenesis.
在雌性F344大鼠中，膀胱内灌注邻苯基苯酚钠（Na-OPP）的代谢产物2-苯基-1,4-苯醌（PBQ），其在生理盐水中的浓度为0.1%，可导致急性上皮损伤、炎症持续和上皮增生。在5周内进行10次这样的PBQ灌注，随后给予5%糖精钠喂养31周，可导致膀胱上皮发生癌前病变。由于Na-OPP本身或另一种代谢产物对苯二酚均未观察到尿路上皮损伤或肿瘤启动活性，因此PBQ可能在Na-OPP诱导的膀胱癌发生中起重要作用。
Zotero 插件