School of Medicine, Surgery, University of Eastern Finland, Kuopio, Finland.
In Vivo. 2010 Nov-Dec;24(6):899-904.
to the Authors' knowledge, the associations between the life stress and losses and deficit in adulthood and the risk of breast cancer (BC) are rarely considered together in a prospective study.
in an extension of the Kuopio Breast Cancer Study, 115 women with breast symptoms were semi-structurally interviewed in-depth, as well as asked to complete standardised questionnaires, and all study variables were obtained before any diagnostic procedures were carried out. The Montgomery-Åsberg depression rating scale (MADRS) was used to evaluate the depression of the study participants.
the clinical examination and biopsy showed BC in 34 patients, benign breast disease (BBD) in 53 patients, and 28 individuals were shown to be healthy (HSS). The BC group had significantly higher mean score for the loss of social status in adulthood than did the BBD and HSS groups (p<0.05). In addition, the women in the BC group had significantly higher mean score for stress in adulthood in the previous 6-10 years (p<0.01), in the previous 2-6 years (p<0.05) and for stress in adulthood in the previous two years (p<0.05) than the women in the BBD and HSS groups. The BC group also had significantly more severe losses in adulthood than the BBD and HSS groups (p<0.01). The results indicated that breast cancer patients tended to have more life stress and losses in adulthood than did those in the BBD and HSS groups.
the results of this study support a weak association between life stress and losses in adulthood and breast cancer risk and it might be that stress and losses impacts indirectly on breast cancer risk, affecting behaviour, or directly on the hypothalamic-pituitary-adrenal axis and autonomic nervous system functioning.
据作者所知，前瞻性研究中很少同时考虑生活压力和成年期的损失与缺陷与乳腺癌（BC）风险之间的关联。
在库奥皮奥乳腺癌研究的扩展中，对 115 名有乳房症状的妇女进行了深入的半结构性访谈，并要求她们完成标准化问卷，并且在进行任何诊断程序之前获得了所有研究变量。使用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）评估研究参与者的抑郁情况。
临床检查和活检显示 34 名患者患有 BC，53 名患者患有良性乳腺疾病（BBD），28 名患者被证明健康（HSS）。BC 组成年期社会地位丧失的平均得分明显高于 BBD 和 HSS 组（p<0.05）。此外，BC 组的成年期压力评分在前 6-10 年（p<0.01）、前 2-6 年（p<0.05）和前两年（p<0.05）的得分明显高于 BBD 和 HSS 组。BC 组的成年期损失也明显多于 BBD 和 HSS 组（p<0.01）。结果表明，乳腺癌患者比 BBD 和 HSS 组患者更容易经历成年期的生活压力和损失。
本研究结果支持成年期生活压力和损失与乳腺癌风险之间存在微弱关联，并且压力和损失可能通过影响行为间接影响乳腺癌风险，或者直接影响下丘脑-垂体-肾上腺轴和自主神经系统功能。
