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急性阑尾炎的保守治疗:异端邪说还是一种有效且可接受的手术替代方法?

Conservative treatment of acute appendicitis: heresy or an effective and acceptable alternative to surgery?

机构信息

Fourth Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, Athens, Greece.

出版信息

Eur J Gastroenterol Hepatol. 2011 Feb;23(2):121-7. doi: 10.1097/MEG.0b013e32834233b6.

DOI:10.1097/MEG.0b013e32834233b6
PMID:21164348
Abstract

For more than a century, emergency appendectomy has been a 'surgical dogma' in the management of acute appendicitis (AA). During recent decades, however, there is an increasing body of evidence suggesting that selected patients with AA could be treated conservatively. This approach has many advantages, including high success and low recurrence rates, reduced morbidity and mortality, less pain, shorter hospitalization and sick leave, and reduced costs. Despite that conservative management of AA cannot be used for all patients with AA (for example, in the presence of peritonitis), it could be preferred in a large percentage of patients with mild infection (as evidenced by clinical, laboratory, and imaging findings).

摘要

一个多世纪以来,在急性阑尾炎(AA)的治疗中,急诊阑尾切除术一直是一种“外科教条”。然而,近几十年来,越来越多的证据表明,一些特定的 AA 患者可以采用保守治疗。这种方法有很多优点,包括高成功率和低复发率、降低发病率和死亡率、减少疼痛、缩短住院和病假时间以及降低成本。尽管 AA 的保守治疗不能用于所有 AA 患者(例如,在腹膜炎的情况下),但它可以在很大一部分感染较轻的患者中优先采用(临床、实验室和影像学检查结果均有证据表明)。

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Conservative treatment of acute appendicitis: heresy or an effective and acceptable alternative to surgery?急性阑尾炎的保守治疗:异端邪说还是一种有效且可接受的手术替代方法?
Eur J Gastroenterol Hepatol. 2011 Feb;23(2):121-7. doi: 10.1097/MEG.0b013e32834233b6.
2
Comparison of operative and non operative management of acute appendicitis.急性阑尾炎手术治疗与非手术治疗的比较。
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A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon).一项比较保守治疗与急性阑尾切除术治疗复杂性阑尾炎(脓肿或蜂窝织炎)的荟萃分析。
Surgery. 2010 Jun;147(6):818-29. doi: 10.1016/j.surg.2009.11.013. Epub 2010 Feb 10.
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[Can acute appendicitis be treated by antibiotics and in what conditions?].[急性阑尾炎能用抗生素治疗吗?在什么情况下可以?]
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Elective versus urgent laparoscopic appendectomy for complicated appendicitis.复杂阑尾炎的择期与急诊腹腔镜阑尾切除术
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Antibiotic therapy and interval appendectomy for perforated appendicitis in children: a selective approach.儿童穿孔性阑尾炎的抗生素治疗及间隔期阑尾切除术:一种选择性方法
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[The pediatric surgeon and acute appendicitis].[小儿外科医生与急性阑尾炎]
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Is acute appendicitis a surgical emergency?急性阑尾炎是外科急症吗?
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Early appendectomy for perforated appendicitis in children should not be abandoned.儿童穿孔性阑尾炎的早期阑尾切除术不应被放弃。
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Conservative treatment of acute appendicitis: an overview.急性阑尾炎的保守治疗:综述
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引用本文的文献

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Afr J Paediatr Surg. 2020 Jan-Jun;17(1-2):23-25. doi: 10.4103/ajps.AJPS_122_16.
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Surgeon. 2021 Apr;19(2):e29-e39. doi: 10.1016/j.surge.2020.07.005. Epub 2020 Aug 11.
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Feasibility, acceptance, safety, and effectiveness of antibiotic therapy as alternative treatment approach to appendectomy in uncomplicated acute appendicitis.
抗生素治疗作为单纯性急性阑尾炎阑尾切除术替代治疗方法的可行性、可接受性、安全性和有效性。
Int J Colorectal Dis. 2019 Nov;34(11):1839-1847. doi: 10.1007/s00384-019-03392-1. Epub 2019 Sep 12.
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Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis.急性单纯性阑尾炎的抗生素治疗:系统评价和荟萃分析。
Int J Colorectal Dis. 2019 Jun;34(6):963-971. doi: 10.1007/s00384-019-03296-0. Epub 2019 Apr 19.
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Delayed appendectomy versus early appendectomy in the treatment of acute appendicitis: a retrospective study.延迟阑尾切除术与早期阑尾切除术治疗急性阑尾炎的疗效比较:一项回顾性研究。
World J Emerg Surg. 2014 Jan 21;9(1):8. doi: 10.1186/1749-7922-9-8.
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Acute appendicitis: what is the gold standard of treatment?急性阑尾炎:治疗的金标准是什么?
World J Gastroenterol. 2013 Dec 21;19(47):8799-807. doi: 10.3748/wjg.v19.i47.8799.
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A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial).一项比较抗生素治疗与阑尾切除术治疗单纯性急性阑尾炎的前瞻性随机对照多中心试验(APPAC试验)。
BMC Surg. 2013 Feb 8;13:3. doi: 10.1186/1471-2482-13-3.
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J Surg Res. 2013 Oct;184(2):723-9. doi: 10.1016/j.jss.2012.12.008. Epub 2012 Dec 27.
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Ann R Coll Surg Engl. 2012 May;94(4):232-4. doi: 10.1308/003588412X13171221590296.
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The NOTA study: non-operative treatment for acute appendicitis: prospective study on the efficacy and safety of antibiotic treatment (amoxicillin and clavulanic acid) in patients with right sided lower abdominal pain.NOTA 研究:急性阑尾炎的非手术治疗:抗生素治疗(阿莫西林和克拉维酸)对右下腹痛患者疗效和安全性的前瞻性研究。
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