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光子晶体平板生物传感器中的灵敏度增强

Sensitivity enhancement in photonic crystal slab biosensors.

作者信息

El Beheiry Mohamed, Liu Victor, Fan Shanhui, Levi Ofer

机构信息

The Edward S Rogers Sr Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto, Ontario M5S 3G4, Canada.

出版信息

Opt Express. 2010 Oct 25;18(22):22702-14. doi: 10.1364/OE.18.022702.

DOI:10.1364/OE.18.022702
PMID:21164609
Abstract

Refractive index sensitivity of guided resonances in photonic crystal slabs is analyzed. We show that modal properties of guided resonances strongly affect spectral sensitivity and quality factors, resulting in substantial enhancement of refractive index sensitivity. A three-fold spectral sensitivity enhancement is demonstrated for suspended slab designs, in contrast to designs with a slab resting over a substrate. Spectral sensitivity values are additionally shown to be unaffected by quality factor reductions, which are common to fabricated photonic crystal nano-structures. Finally, we determine that proper selection of photonic crystal slab design parameters permits biosensing of a wide range of analytes, including proteins, antigens, and cells. These photonic crystals are compatible with large-area biosensor designs, permitting direct access to externally incident optical beams in a microfluidic device.

摘要

分析了光子晶体平板中导模共振的折射率灵敏度。我们表明,导模共振的模态特性强烈影响光谱灵敏度和品质因数,从而导致折射率灵敏度大幅提高。与平板置于衬底上的设计相比,悬浮平板设计的光谱灵敏度提高了三倍。此外,光谱灵敏度值不受品质因数降低的影响,品质因数降低在制造的光子晶体纳米结构中很常见。最后,我们确定,适当选择光子晶体平板设计参数可实现对包括蛋白质、抗原和细胞在内的多种分析物的生物传感。这些光子晶体与大面积生物传感器设计兼容,可在微流控装置中直接接入外部入射光束。

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Sensitivity enhancement in photonic crystal slab biosensors.光子晶体平板生物传感器中的灵敏度增强
Opt Express. 2010 Oct 25;18(22):22702-14. doi: 10.1364/OE.18.022702.
2
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