Austin M P, Souza F G, Goodwin G M
Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital.
Br J Psychiatry. 1991 Oct;159:510-4. doi: 10.1192/bjp.159.4.510.
A quantitative analysis was used to examine the efficacy of lithium augmentation in the acute treatment of depressed patients resistant to a standard trial of an antidepressant. Effect sizes were measured by the odds ratio using the Mantel-Haenszel method. Only controlled trials were included in order to minimise bias in method. A highly statistically significant effect for lithium augmentation was found, the pooled odds ratio being 0.146 and its 95% confidence interval 0.05-0.44 (i.e. the odds of remaining ill are reduced by between 56% and 95% with the use of lithium treatment). While these results support the case for lithium augmentation in treatment-resistant depression, there remains considerable uncertainty over the duration of treatment necessary to see and sustain the treatment response.
采用定量分析来检验锂盐增效在抗抑郁药标准治疗试验无效的抑郁症患者急性治疗中的疗效。效应量通过使用Mantel-Haenszel方法的优势比来衡量。仅纳入对照试验以尽量减少方法上的偏倚。发现锂盐增效具有高度统计学意义的效果，合并优势比为0.146，其95%置信区间为0.05 - 0.44（即使用锂盐治疗后病情持续的几率降低了56%至95%）。虽然这些结果支持锂盐增效用于治疗抵抗性抑郁症的情况，但对于观察和维持治疗反应所需的治疗持续时间仍存在相当大的不确定性。
