作为疫苗载体的致病菌：教老细菌新技巧。
Pathogenic bacteria as vaccine vectors: teaching old bugs new tricks.
机构信息
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Yale J Biol Med. 2010 Dec;83(4):217-22.
Abstract
As our scientific knowledge of bacteria grows, so does our ability to manipulate these bacteria to protect rather than infect mammalian hosts from a diverse group of diseases. The old axiom that the best way to protect from a disease is to get infected in the first place is not feasible in the face of the diverse group of pathogens that infect humans. Therefore, reprogramming bacteria to protect against diverse bacterial, viral, and parasitic diseases as well as cancer is a new reality in the field of vaccines.
摘要
随着我们对细菌的科学认识不断增长，我们操纵这些细菌的能力也在增强，以保护而不是感染哺乳动物宿主免受各种疾病的侵害。面对感染人类的各种病原体，“最好的预防疾病的方法是首先感染”这一古老的格言已不再可行。因此，对细菌进行重新编程以预防各种细菌、病毒和寄生虫疾病以及癌症，这在疫苗领域已成为一种新的现实。
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