Centro de Biotecnologia, Instituto Butantan, Av. Vital Brasil 1500, São Paulo, SP, Brazil.
Braz J Med Biol Res. 2011 Jun;44(6):500-13. doi: 10.1590/s0100-879x2011007500064. Epub 2011 May 13.
Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvants in a more rational design. The purpose of this review is to discuss the recent advances in this field regarding the attempts to determine the molecular basis and the general mechanisms underlying the development of new adjuvants, with particular emphasis on the activation of receptors of innate immune recognition. One can anticipate that the use of these novel adjuvants will also provide a window of opportunities for the development of new vaccines.
铝盐已被广泛应用于疫苗制剂中，自 80 多年前引入以来，在过去的二十年中，仅开发了少数使用新型佐剂的疫苗制剂。最近对先天机制如何影响适应性免疫的理解的进展为新佐剂的开发提供了更合理的设计的可能性。本文的目的是讨论该领域的最新进展，尝试确定新佐剂开发的分子基础和一般机制，特别强调先天免疫识别受体的激活。人们可以预期，这些新型佐剂的使用也将为新疫苗的开发提供机会。
