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纳米医学:对抗微生物感染的新前沿。

Nanomedicine: New Frontiers in Fighting Microbial Infections.

作者信息

Mehrabi Mohammad Reza, Soltani Madjid, Chiani Mohsen, Raahemifar Kaamran, Farhangi Ali

机构信息

Department of NanoBiotechnology, Pasteur Institute of Iran, Tehran 13169-43551, Iran.

Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran 19967-15433, Iran.

出版信息

Nanomaterials (Basel). 2023 Jan 25;13(3):483. doi: 10.3390/nano13030483.

Abstract

Microbes have dominated life on Earth for the past two billion years, despite facing a variety of obstacles. In the 20th century, antibiotics and immunizations brought about these changes. Since then, microorganisms have acquired resistance, and various infectious diseases have been able to avoid being treated with traditionally developed vaccines. Antibiotic resistance and pathogenicity have surpassed antibiotic discovery in terms of importance over the course of the past few decades. These shifts have resulted in tremendous economic and health repercussions across the board for all socioeconomic levels; thus, we require ground-breaking innovations to effectively manage microbial infections and to provide long-term solutions. The pharmaceutical and biotechnology sectors have been radically altered as a result of nanomedicine, and this trend is now spreading to the antibacterial research community. Here, we examine the role that nanomedicine plays in the prevention of microbial infections, including topics such as diagnosis, antimicrobial therapy, pharmaceutical administration, and immunizations, as well as the opportunities and challenges that lie ahead.

摘要

在过去的二十亿年里,微生物一直主导着地球上的生命,尽管面临着各种各样的障碍。在20世纪,抗生素和免疫接种带来了这些变化。从那时起,微生物获得了耐药性,各种传染病得以避免使用传统开发的疫苗进行治疗。在过去几十年里,抗生素耐药性和致病性在重要性方面已经超过了抗生素的发现。这些转变给所有社会经济层面都带来了巨大的经济和健康影响;因此,我们需要突破性的创新来有效管理微生物感染并提供长期解决方案。纳米医学已经从根本上改变了制药和生物技术领域,并且这一趋势现在正在蔓延到抗菌研究领域。在这里,我们研究纳米医学在预防微生物感染中所起的作用,包括诊断、抗菌治疗、药物给药和免疫接种等主题,以及未来面临的机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff7/9920255/3b1f82d8468a/nanomaterials-13-00483-g006.jpg

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