Scientific Affairs, Danone Research, Palaiseau, France.
Eur J Health Econ. 2012 Feb;13(1):101-10. doi: 10.1007/s10198-010-0289-4. Epub 2010 Dec 17.
The objective of this study was to assess the cost-effectiveness of the use of prebiotics for the primary prevention of atopic dermatitis in The Netherlands. A model was constructed using decision analytical techniques. The model was developed to estimate the health economic impact of prebiotic preventive disease management of atopic dermatitis. Data sources used include published literature, clinical trials and official price/tariff lists and national population statistics. The comparator was no supplementation with prebiotics. The primary perspective for conducting the economic evaluation was based on the situation in The Netherlands in 2009. The results show that the use of prebiotics infant formula (IMMUNOFORTIS(®)) leads to an additional cost of € 51 and an increase in Quality Adjusted Life Years (QALY) of 0.108, when compared with no prebiotics. Consequently, the use of infant formula with a specific mixture of prebiotics results in an incremental cost-effectiveness ratio (ICER) of € 472. The sensitivity analyses show that the ICER remains in all analyses far below the threshold of € 20,000/QALY.
This study shows that the favourable health benefit of the use of a specific mixture of prebiotics results in positive short- and long-term health economic benefits. In addition, this study demonstrates that the use of infant formula with a specific mixture of prebiotics is a highly cost-effective way of preventing atopic dermatitis in The Netherlands.
本研究旨在评估在荷兰使用益生元预防特应性皮炎的成本效益。使用决策分析技术构建了一个模型。该模型旨在估计益生元预防特应性皮炎的疾病管理对健康经济的影响。使用的数据来源包括已发表的文献、临床试验以及官方价格/关税清单和国家人口统计数据。对照组为不补充益生元。进行经济评估的主要观点是基于 2009 年荷兰的情况。研究结果表明，与不使用益生元相比，使用含有特定益生元混合物的婴儿配方奶粉（IMMUNOFORTIS（®））会额外增加 51 欧元的成本，并增加 0.108 个质量调整生命年（QALY）。因此，使用含有特定混合物的婴儿配方奶粉会导致增量成本效益比（ICER）为 472 欧元。敏感性分析表明，在所有分析中，ICER 均远低于 20,000 欧元/QALY 的阈值。
本研究表明，使用特定混合物的益生元可带来有利的健康效益，从而带来短期和长期的健康经济效益。此外，本研究表明，在荷兰，使用含有特定混合物的婴儿配方奶粉是预防特应性皮炎的一种非常具有成本效益的方法。
