Foolad N, Armstrong A W
Department of Dermatology, University of California at Davis School of Medicine, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA.
Benef Microbes. 2014 Jun 1;5(2):151-60. doi: 10.3920/BM2013.0034.
The purpose of this review was to identify whether supplementation with prebiotics and/or probiotics help prevent the development or reduce the severity of atopic dermatitis in children less than three years of age. Since 1997, immunostimulatory supplements, such as prebiotics and probiotics, have been investigated. Various supplementations include probiotics (single strain or mix), probiotics with formula, probiotics mix with prebiotics, and prebiotics. In this narrative review, we examined 13 key articles on prebiotics and/or probiotics, and their effects on infant atopic dermatitis. Among the selected studies, a total of 3,023 participants received supplements or placebo. Eight out of the 13 (61.5%) studies reported a significant effect on the prevention of atopic dermatitis after supplementation with probiotics and/or prebiotics. Five out of the 13 (38.5%) studies indicated significant reduction in the severity of atopic dermatitis after supplementation. Based on the available studies, supplementation with certain probiotics (Lactobacillus rhamnosus GG) appears to be an effective approach for the prevention and reduction in severity of atopic dermatitis. A mix of specific probiotic strains prevented atopic dermatitis among infants. Based on studies with prebiotics, there was a long-term reduction in the incidence of atopic dermatitis. Supplementation with prebiotics and probiotics appears useful for the reduction in the severity of atopic dermatitis. Additional interventional studies exploring prebiotics and probiotics are imperative before recommendations can be made.
本综述的目的是确定补充益生元和/或益生菌是否有助于预防三岁以下儿童特应性皮炎的发生或减轻其严重程度。自1997年以来，人们一直在研究免疫刺激补充剂，如益生元和益生菌。各种补充方式包括益生菌（单一菌株或混合菌株）、含配方奶的益生菌、益生菌与益生元的混合制剂以及益生元。在这篇叙述性综述中，我们研究了13篇关于益生元和/或益生菌及其对婴儿特应性皮炎影响的关键文章。在所选研究中，共有3023名参与者接受了补充剂或安慰剂。13项研究中的8项（61.5%）报告称，补充益生菌和/或益生元后对预防特应性皮炎有显著效果。13项研究中的5项（38.5%）表明补充后特应性皮炎的严重程度显著降低。基于现有研究，补充某些益生菌（鼠李糖乳杆菌GG）似乎是预防和减轻特应性皮炎严重程度的有效方法。特定益生菌菌株的组合可预防婴儿患特应性皮炎。基于对益生元的研究，特应性皮炎的发病率有长期下降。补充益生元和益生菌似乎有助于减轻特应性皮炎的严重程度。在提出建议之前，必须进行更多探索益生元和益生菌的干预性研究。
