Case Western Reserve University Medical School, Cleveland, Ohio, USA.
J Surg Oncol. 2011 Jan 1;103(1):85-91. doi: 10.1002/jso.21763.
In sarcoma patients the roles of smoking history, family cancer history, and leukoreduced blood transfusions have not been studied and the effect of preoperative radiation on blood loss has not been examined.
Seventy-seven patients with non-metastatic and non-recurrent thigh sarcomas surgically treated at the Cleveland Clinic were identified. Among patient variables studied were: close family history of cancer, perioperative transfusion history, smoking history, and radiation history. Median follow-up for the survivors was 3.2 years.
We found that tumor grade, transfusion >3 U (P = 0.022), and pre- or post-operative radiation therapy (P = 0.041) were risk factors for distant metastasis. Tumor grade (P = 0.008), positive smoking history (P = 0.039), and >3 U of non-leukoreduced blood transfused (P = 0.037) were risk factors for death of any-cause. Close family history of cancer correlated with having a grade 3 sarcoma (P = 0.044). Neoadjuvant radiotherapy correlated with >3 U of blood transfused (P = 0.001) and biopsy performed at the treating institution led to a significant decrease in rate of recurrence (P = 0.016).
We present novel findings in terms of transfusions, family history of cancer and site of initial biopsy in sarcoma patients.
在肉瘤患者中，吸烟史、家族癌症史和去白细胞输血的作用尚未得到研究，术前放疗对出血量的影响也尚未得到检验。
在克利夫兰诊所，我们确定了 77 名接受非转移性和非复发性大腿肉瘤手术治疗的患者。在研究的患者变量中包括：近亲的癌症史、围手术期输血史、吸烟史和放疗史。幸存者的中位随访时间为 3.2 年。
我们发现肿瘤分级、输血>3U（P=0.022）和术前或术后放疗（P=0.041）是远处转移的危险因素。肿瘤分级（P=0.008）、阳性吸烟史（P=0.039）和非去白细胞输血>3U（P=0.037）是任何原因死亡的危险因素。近亲的癌症史与 3 级肉瘤相关（P=0.044）。新辅助放疗与输血>3U 相关（P=0.001），在治疗机构进行的活检导致复发率显著降低（P=0.016）。
我们提出了有关肉瘤患者输血、家族癌症史和初次活检部位的新发现。
