黎巴嫩软组织和骨肉瘤的描述性流行病学。
Descriptive epidemiology of soft tissue and bone sarcomas in Lebanon.
机构信息
Department of Internal Medicine, Division of Hematology and Oncology, Naef K. Basile Cancer Institute, 66984American University of Beirut Medical Center, American University of Beirut Medical Center, Beirut, Lebanon.
Department of Pediatrics, 66984American University of Beirut Medical Center, American University of Beirut Medical Center, Beirut, Lebanon.
出版信息
J Int Med Res. 2022 Mar;50(3):3000605221082852. doi: 10.1177/03000605221082852.
OBJECTIVES
Most epidemiologic studies on soft tissue sarcomas (STS) and bone sarcomas (BS) are performed in western countries, with few in the Middle East and North Africa region. We describe the epidemiology of sarcomas in Lebanon using the medical records database at the American University of Beirut Medical Center (AUBMC).
METHODS
This single-center retrospective cohort study included patients with sarcomas registered in the database between 2015 and 2019. Their charts were reviewed for baseline characteristics, tumor biology and location, treatment modalities, recurrence, metastasis, and death.
RESULTS
The cohort included 234 patients with STS and 99 patients with BS. Most tumors were <10 cm in size. The most common subtypes were liposarcoma for STS and osteosarcoma for BS. The most common location of STS was the thigh. The most frequent sites of STS metastasis were the lungs. Histological subtype, smoking status, and tumor size and grade were significant for progression-free survival (PFS) in patients with STS. By multivariable analysis, smoking was significantly associated with poorer PFS in STS. For BS, only tumor grade was significant for PFS.
CONCLUSION
The epidemiology of sarcomas at AUBMC is similar to that previously reported. Smoking history was associated with poorer survival in patients with STS.
目的
大多数软组织肉瘤（STS）和骨肉瘤（BS）的流行病学研究都是在西方国家进行的，中东和北非地区的研究较少。我们使用贝鲁特美国大学医学中心（AUBMC）的病历数据库来描述黎巴嫩肉瘤的流行病学情况。
方法
这项单中心回顾性队列研究纳入了 2015 年至 2019 年期间在数据库中登记的肉瘤患者。对其病历进行了基线特征、肿瘤生物学和位置、治疗方式、复发、转移和死亡情况的回顾。
结果
该队列包括 234 例 STS 患者和 99 例 BS 患者。大多数肿瘤<10cm。最常见的亚型是 STS 的脂肪肉瘤和 BS 的骨肉瘤。STS 最常见的部位是大腿。STS 转移最常见的部位是肺部。STS 患者的无进展生存期（PFS）与组织学亚型、吸烟状况以及肿瘤大小和分级显著相关。多变量分析显示，STS 患者的吸烟与较差的 PFS 显著相关。对于 BS，只有肿瘤分级与 PFS 显著相关。
结论
AUBMC 的肉瘤流行病学与之前报道的相似。吸烟史与 STS 患者的生存率较差相关。
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