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左心房的磁共振成像:预测心房颤动患者的临床结局

MRI of the left atrium: predicting clinical outcomes in patients with atrial fibrillation.

作者信息

Daccarett Marcos, McGann Chris J, Akoum Nazem W, MacLeod Rob S, Marrouche Nassir F

机构信息

Division of Cardiology, University of Utah Health Sciences Center, 30 North 1900 East, Room 4A100, Salt Lake City, UT 84132, USA.

出版信息

Expert Rev Cardiovasc Ther. 2011 Jan;9(1):105-11. doi: 10.1586/erc.10.177.

Abstract

Atrial fibrillation is a significant public health burden, with clinically, epidemiologically and economically significant repercussions. In the last decade, catheter ablation has provided an improvement in morbidity and quality of life, significantly reducing long-term healthcare costs and avoiding recurrences compared with drug therapy. Despite recent progress in techniques, current catheter ablation success rates fall short of expectations. Late gadolinium-enhancement cardiovascular MRI is a well-established tool to image the myocardium and, most specifically, the left atrium. Unique imaging protocols allow for left atrial structural remodeling and fibrosis assessment, which has been demonstrated to correlate with clinical outcomes after catheter ablation, assessment of the individual's risks of thromboembolic events, and effective imaging of patients with left atrial appendage thrombus. Late gadolinium-enhancement MRI aids in the individualized treatment of atrial fibrillation, stratifying recurrence risk and guiding specific ablation strategies. Real-time MRI offers significant safety and effectiveness profiles that would optimize the invasive treatment of atrial fibrillation.

摘要

心房颤动是一项重大的公共卫生负担,在临床、流行病学和经济方面均产生重大影响。在过去十年中,与药物治疗相比,导管消融术已改善了发病率和生活质量,显著降低了长期医疗成本并避免了复发。尽管技术上最近有所进展,但目前导管消融的成功率仍未达预期。延迟钆增强心血管磁共振成像(MRI)是一种成熟的用于心肌成像,尤其是左心房成像的工具。独特的成像方案可用于评估左心房结构重塑和纤维化,这已被证明与导管消融术后的临床结果、个体血栓栓塞事件风险评估以及左心耳血栓患者的有效成像相关。延迟钆增强MRI有助于心房颤动的个体化治疗,对复发风险进行分层并指导特定的消融策略。实时MRI具有显著的安全性和有效性,将优化心房颤动的侵入性治疗。

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