Mahafzah M, Stadler S, Qazi K, Ambrus J L
Department of Medicine, Sister's of Charity Hospital, Buffalo, NY.
Thromb Res. 1990 Mar 15;57(6):925-34. doi: 10.1016/0049-3848(90)90159-a.
Sodium Meclofenamate, (Meclomen) (M) is a non-steroidal anti-inflammatory drug, which inhibits both cyclooxygenases and lipooxygenases of the arachidonic acid cascade (AA). (M) inhibited adenosine diphosphosphate (ADP) induced platelet aggregation, arachidonic acid (AA) induced platelet aggregation and collagen induced platelet aggregation. (M) inhibited platelet factor 3 availability when measured by Stypven clotting time. Red cells from patients with advanced malignancies and normal red cells stored in blood banks exhibited loss of deformability. (M) enhanced red cell deformability in these blood samples.
甲氯芬那酸钠（甲氯灭酸）是一种非甾体抗炎药，它能抑制花生四烯酸级联反应中的环氧化酶和脂氧合酶。甲氯芬那酸钠抑制二磷酸腺苷诱导的血小板聚集、花生四烯酸诱导的血小板聚集以及胶原诱导的血小板聚集。在用蛇毒凝血时间测量时，甲氯芬那酸钠抑制血小板因子3的活性。晚期恶性肿瘤患者的红细胞和血库中储存的正常红细胞均表现出变形能力丧失。甲氯芬那酸钠可增强这些血样中红细胞的变形能力。
