Kostiuk V A, Potapovich A I, Soroka N F
Vopr Med Khim. 1990 May-Jun;36(3):37-9.
Antioxidative activity of acetyl salicylic acid, indometacin, ibuprophen, orthophen, delagil, D-penicillamine and levamysol was studied under conditions of NADPH- and CCl4-dependent lipid peroxidation both in rat liver microsomes and in adrenaline autioxidation. All the drugs studied exhibited only slight antioxidative activity being dissolved in mater, and especially towards lipid peroxidation, as compared with quercitrol and ionol; their activity was noted at concentrations exceeding distinctly the therapeutic doses. At the same time, D-penicillamine inhibited lipid peroxidation not only by means of free radicals neutralization but also via binding of iron ions. This property of the drug may be responsible for its effects, to some extent, in treatment of joint inflammations.
在大鼠肝微粒体中以及肾上腺素自氧化过程中，在NADPH和四氯化碳依赖性脂质过氧化条件下，研究了乙酰水杨酸、吲哚美辛、布洛芬、邻苯酚、地拉吉、D-青霉胺和左旋咪唑的抗氧化活性。与槲皮醇和离子醇相比，所有研究的药物溶解于水中时仅表现出轻微的抗氧化活性，尤其是对脂质过氧化的活性；它们在明显超过治疗剂量的浓度下才有活性。同时，D-青霉胺不仅通过中和自由基，还通过结合铁离子来抑制脂质过氧化。该药物的这一特性在一定程度上可能与其治疗关节炎症的效果有关。
