Nawaz M, Tabassum R, Iqbal T, Perveen Z
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Zentralbl Veterinarmed A. 1990 May;37(4):247-52. doi: 10.1111/j.1439-0442.1990.tb00901.x.
Disposition kinetics, renal clearance and urinary excretion of ampicillin were determined after oral administration of 10 mg/kg in 8 goats. Peak plasma concentration 1.86 +/- 0.14 mumol/l was attained at 117 +/- 11 min after oral administration. Half-time of absorption was 28.7 +/- 5.8 minutes and that of elimination was 135 +/- 15 minutes. Total area under plasma concentration versus time curve was 9.16 +/- 0.97 mumol.h/l. Total body clearance of ampicillin was 52.1 +/- 4.2 and renal clearance was 0.07 +/- 0.008 ml/min.kg. The renal handling of ampicillin involved glomerular filtration and back diffusion.
给8只山羊口服10mg/kg氨苄西林后,测定其处置动力学、肾脏清除率及尿排泄情况。口服给药后117±11分钟达到血浆峰值浓度1.86±0.14μmol/l。吸收半衰期为28.7±5.8分钟,消除半衰期为135±15分钟。血浆浓度-时间曲线下总面积为9.16±0.97μmol·h/l。氨苄西林的总体清除率为52.1±4.2,肾脏清除率为0.07±0.008ml/min·kg。氨苄西林的肾脏处理过程包括肾小球滤过和反向扩散。