Whittaker J S, Ryan C F, Buckley P A, Road J D
Department of Medicine, University of British Columbia, Vancouver, Canada.
Am Rev Respir Dis. 1990 Aug;142(2):283-8. doi: 10.1164/ajrccm/142.2.283.
We carried out a prospective randomized controlled trial to investigate the effects of short-term refeeding (16 days) in 10 malnourished inpatients with chronic obstructive pulmonary disease (COPD). Six patients were randomized to receive sufficient nasoenterically administered calories to provide a total caloric intake equal to 1,000 kcal above their usual intake. The other four patients were sham fed, receiving only 100 kcal more. Measurements of nutritional status, respiratory muscle strength and endurance, adductor pollicis function, and pulmonary function were performed initially and at study end. The refed group gained significantly more weight and showed significant increases in maximal expiratory pressure and mean sustained inspiratory pressure. There were no significant changes in the maximal inspiratory pressure or in adductor pollicis function. In malnourished inpatients with COPD, short-term refeeding leads to improvement in respiratory muscle endurance and in some parameters of respiratory muscle strength in the absence of demonstrable changes in peripheral muscle function.
我们进行了一项前瞻性随机对照试验，以研究短期再喂养（16天）对10例慢性阻塞性肺疾病（COPD）营养不良住院患者的影响。6例患者被随机分配接受经鼻肠给予足够的热量，使总热量摄入比其通常摄入量高1000千卡。其他4例患者接受假喂养，仅多摄入100千卡。在研究开始时和结束时对营养状况、呼吸肌力量和耐力、拇内收肌功能及肺功能进行了测量。再喂养组体重增加显著更多，最大呼气压力和平均持续吸气压力显著升高。最大吸气压力或拇内收肌功能无显著变化。在COPD营养不良住院患者中，短期再喂养可改善呼吸肌耐力和一些呼吸肌力量参数，而外周肌肉功能无明显变化。
