Sabrkhany Siamack, Griffioen Arjan W, Oude Egbrink Mirjam G A
Laboratory for Microcirculation, Cardiovascular Research Institute Maastricht (CARIM), Dept. of Physiology, Maastricht, The Netherlands.
Biochim Biophys Acta. 2011 Apr;1815(2):189-96. doi: 10.1016/j.bbcan.2010.12.001. Epub 2010 Dec 16.
Coagulation abnormalities occur frequently in cancer patients. It is becoming evident that blood platelets have an important function in this process. However, understanding of the underlying mechanisms is still very modest. In this review, we discuss the role of platelets in tumor angiogenesis and growth and suggest their potential significance in malignancies. Platelets contain various pro-and antiangiogenic molecules, which seem to be endocytosed and sequestered in different populations of α-granules. Furthermore, tumor endothelial cells are phenotypically and functionally different from endothelial cells in healthy tissue, stimulating local platelet adhesion and subsequent activation. As a consequence, platelets are able to secrete their angiogenic and angiostatic content, most likely in a regulated manner. The overall effect of these platelet-endothelium interactions appears to be proangiogenic, stimulating tumor angiogenesis. We favor the view that local adhesion and activation of blood platelets and dysregulation of coagulation represent underestimated pathways in the progression of cancer.
凝血异常在癌症患者中经常出现。越来越明显的是，血小板在这一过程中具有重要作用。然而，对其潜在机制的了解仍然非常有限。在这篇综述中，我们讨论了血小板在肿瘤血管生成和生长中的作用，并提出它们在恶性肿瘤中的潜在意义。血小板含有各种促血管生成和抗血管生成分子，这些分子似乎被内吞并隔离在不同群体的α颗粒中。此外，肿瘤内皮细胞在表型和功能上与健康组织中的内皮细胞不同，会刺激局部血小板黏附并随后激活。因此，血小板能够以一种很可能是受调控的方式分泌其血管生成和血管抑制成分。这些血小板-内皮细胞相互作用的总体效果似乎是促血管生成的，刺激肿瘤血管生成。我们赞同这样一种观点，即血小板的局部黏附与激活以及凝血失调是癌症进展中被低估的途径。
