Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56100 Pisa, Italy.
J Chem Neuroanat. 2011 Dec;42(4):288-96. doi: 10.1016/j.jchemneu.2010.12.002. Epub 2010 Dec 16.
In this short overview a reappraisal of the anatomical connections of vagal afferents is reported. The manuscript moves from classic neuroanatomy to review details of vagus nerve anatomy which are now becoming more and more relevant for clinical outcomes (i.e. the therapeutic use of vagus nerve stimulation). In drawing such an updated odology of central vagal connections the anatomical basis subserving the neurochemical effects of vagal stimulation are addressed. In detail, apart from the thalamic projection of central vagal afferents, the monoaminergic systems appear to play a pivotal role. Stemming from the chemical neuroanatomy of monoamines such as serotonin and norepinephrine the widespread effects of vagal stimulation on cerebral cortical activity are better elucidated. This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders.
在这篇简短的综述中，报告了对迷走神经传入的解剖连接的重新评估。本文从经典神经解剖学出发，回顾了迷走神经解剖学的细节，这些细节现在对于临床结果（即迷走神经刺激的治疗应用）越来越重要。在绘制这种更新的中央迷走神经连接的解剖学图谱时，探讨了迷走神经刺激的神经化学作用的解剖学基础。具体来说，除了中央迷走神经传入的丘脑投射外，单胺能系统似乎起着关键作用。从 5-羟色胺和去甲肾上腺素等单胺类的化学神经解剖学出发，更好地阐明了迷走神经刺激对大脑皮质活动的广泛影响。这既涉及抗癫痫作用，也涉及迷走神经刺激在情绪和认知障碍中的最近益处。
