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Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.

作者信息

Ozaki Y, Matsumoto Y, Yatomi Y, Higashihara M, Kariya T, Kume S

机构信息

Department of Clinical and Laboratory Medicine, Yamanashi Medical College, Japan.

出版信息

Biochem Biophys Res Commun. 1990 Jul 31;170(2):779-85. doi: 10.1016/0006-291x(90)92159-w.

DOI:10.1016/0006-291x(90)92159-w
PMID:2116797
Abstract

Mastoparan induced limited release of serotonin from intact human platelets, while neither intracellular calcium ion elevation nor arachidonic acid mobilization was observed. Cytolysis induced by mastoparan was negligible in the concentration range that induced serotonin release. In digitonin-permeabilized cells, mastoparan induced Ca(++)-independent release of serotonin and Ca(++)-dependent arachidonic acid release. Both serotonin release and arachidonic acid release were reduced by pertussis toxin, suggesting that platelet activation induced by mastoparan is mediated by GTP-binding proteins.

摘要

相似文献

1
Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.
Biochem Biophys Res Commun. 1990 Jul 31;170(2):779-85. doi: 10.1016/0006-291x(90)92159-w.
2
Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein.蜂毒肽是一种黄蜂毒液，它通过百日咳毒素敏感的GTP结合蛋白刺激胰岛释放胰岛素。
Biochem Biophys Res Commun. 1989 Feb 15;158(3):712-6. doi: 10.1016/0006-291x(89)92779-4.
3
Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein.嗜铬细胞中的胞吐作用：存在一个不依赖MgATP的步骤的证据，该步骤需要一种对百日咳毒素敏感的GTP结合蛋白。
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27. doi: 10.1042/bj3000217.
4
Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.马斯托帕兰是一种对瑞士3T3细胞有活性的新型促细胞分裂剂，可刺激百日咳毒素敏感的花生四烯酸释放，而不会积累肌醇磷酸。
J Cell Biol. 1991 May;113(4):943-50. doi: 10.1083/jcb.113.4.943.
5
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).蜂毒肽是一种来自黄蜂毒液的肽毒素，它通过激活鸟苷酸结合调节蛋白（G蛋白）来模拟受体。
J Biol Chem. 1988 May 15;263(14):6491-4.
6
Mastoparan promotes exocytosis and increases intracellular cyclic AMP in human platelets. Evidence for the existence of a Ge-like mechanism of secretion.肥大细胞脱粒肽促进人血小板的胞吐作用并增加细胞内的环磷酸腺苷。存在类Ge分泌机制的证据。
Biochem J. 1992 Jan 15;281 ( Pt 2)(Pt 2):465-72. doi: 10.1042/bj2810465.
7
Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells.马斯托帕兰通过人星形细胞瘤细胞中对百日咳毒素不敏感的G蛋白抑制磷酸肌醇水解。 （注：原英文文本中“[corrected]”在中文里较难直接对应，已按整体意思翻译，若有特殊要求可进一步说明处理方式）
FEBS Lett. 1990 Jan 15;260(1):91-4. doi: 10.1016/0014-5793(90)80074-s.
8
Pertussis toxin-insensitive effects of mastoparan, a wasp venom peptide, in PC12 cells.黄蜂毒液肽马斯托帕兰在PC12细胞中的百日咳毒素不敏感效应。
J Cell Physiol. 1996 Dec;169(3):448-54. doi: 10.1002/(SICI)1097-4652(199612)169:3<448::AID-JCP5>3.0.CO;2-O.
9
The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.异三聚体G蛋白Gi定位于β细胞的胰岛素分泌颗粒，并参与胰岛素胞吐作用。
J Biol Chem. 1995 May 26;270(21):12869-76. doi: 10.1074/jbc.270.21.12869.
10
Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin.葡萄糖可激活胰腺β细胞中三聚体GTP结合蛋白γ亚基的羧基甲基化。体内受钙、GTP和百日咳毒素的调节。
J Clin Invest. 1997 Sep 15;100(6):1596-610. doi: 10.1172/JCI119684.

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Parasitol Res. 2015 Feb;114(2):359-77. doi: 10.1007/s00436-014-4260-7. Epub 2014 Dec 30.
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Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation.鉴定硫醇异构酶结合肽——蜂毒素——为剪切诱导的转化生长因子β1（TGF-β1）激活的新型抑制剂。
J Biol Chem. 2013 Apr 12;288(15):10628-39. doi: 10.1074/jbc.M112.439034. Epub 2013 Mar 5.
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J Exp Bot. 2010 Mar;61(3):747-54. doi: 10.1093/jxb/erp339. Epub 2009 Dec 9.
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Venom effects on monoaminergic systems.毒液对单胺能系统的影响。
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Ca(2+)-independent fusion of synaptic vesicles with phospholipase A2-treated presynaptic membranes in vitro.体外突触小泡与经磷脂酶A2处理的突触前膜的钙离子非依赖性融合
Biochem J. 1996 Sep 15;318 ( Pt 3)(Pt 3):981-7. doi: 10.1042/bj3180981.
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Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.在人星形细胞瘤细胞中，蜂毒肽通过激活磷脂酶D诱导磷脂酰胆碱水解。
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