Moreno Miguel, Giralt Ernest
Chemistry and Molecular Pharmacology, Institute for Research in Biomedicine (IRB Barcelona), Baldiri i Reixac, 10, Barcelona 08028, Spain.
Toxins (Basel). 2015 Apr 1;7(4):1126-50. doi: 10.3390/toxins7041126.
While knowledge of the composition and mode of action of bee and wasp venoms dates back 50 years, the therapeutic value of these toxins remains relatively unexploded. The properties of these venoms are now being studied with the aim to design and develop new therapeutic drugs. Far from evaluating the extensive number of monographs, journals and books related to bee and wasp venoms and the therapeutic effect of these toxins in numerous diseases, the following review focuses on the three most characterized peptides, namely melittin, apamin, and mastoparan. Here, we update information related to these compounds from the perspective of applied science and discuss their potential therapeutic and biotechnological applications in biomedicine.
虽然对蜜蜂和黄蜂毒液的成分及作用方式的了解可追溯到50年前，但这些毒素的治疗价值仍相对未被充分发掘。目前正在研究这些毒液的特性，旨在设计和开发新的治疗药物。以下综述并非评估与蜜蜂和黄蜂毒液以及这些毒素在众多疾病中的治疗效果相关的大量专著、期刊和书籍，而是聚焦于三种特征最为明显的肽，即蜂毒肽、蜂毒明肽和马斯托帕兰。在此，我们从应用科学的角度更新与这些化合物相关的信息，并讨论它们在生物医学中的潜在治疗和生物技术应用。
