Division of Reproductive Endocrinology and Fertility, Department of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina, USA.
Fertil Steril. 2011 Apr;95(5):1786.e13-6. doi: 10.1016/j.fertnstert.2010.11.016. Epub 2010 Dec 18.
To report a case of late ovarian hyperstimulation syndrome (OHSS) in a woman with lupus nephritis undergoing controlled ovarian stimulation and in vitro fertilization (IVF) with subsequent transfer into a gestational surrogate.
A case report.
Academic reproductive medicine clinic.
PATIENT(S): A 33-year-old woman who presented 10 days after recombinant human chorionic gonadotropin (hCG) injection with fatigue, abdominal pain, and bloating, diagnosed as OHSS.
INTERVENTION(S): Patient admitted for intravenous fluid hydration, anticoagulation, and gonadotropin-releasing hormone (GnRH) antagonist therapy.
MAIN OUTCOME MEASURE(S): Successful detection and management of severe OHSS in a patient with chronically impaired kidney function.
RESULT(S): The patient has returned to her baseline condition, and the gestational carrier was noted to have a twin gestation.
CONCLUSION(S): In patients with impaired renal function, final oocyte maturation should be triggered with a GnRH agonist rather than hCG.
报告 1 例狼疮性肾炎患者行控制性卵巢刺激和体外受精（IVF）后，进行妊娠代孕，并随后发生晚期卵巢过度刺激综合征（OHSS）。
病例报告。
学术生殖医学诊所。
一名 33 岁女性，在接受重组人绒毛膜促性腺激素（hCG）注射后 10 天出现疲劳、腹痛和腹胀，被诊断为 OHSS。
患者接受静脉补液、抗凝和促性腺激素释放激素（GnRH）拮抗剂治疗。
成功检测和治疗慢性肾功能不全患者的严重 OHSS。
患者已恢复到基线状态，妊娠代孕者被发现怀有双胞胎。
在肾功能受损的患者中，最终卵母细胞成熟应使用 GnRH 激动剂而不是 hCG 触发。
