Services de Gynécologie Obstétrique et Médecine de la Reproduction, Centre Hospitalier Universitaire Jean Verdier, Paris, France.
Eur J Obstet Gynecol Reprod Biol. 2011 Apr;155(2):183-7. doi: 10.1016/j.ejogrb.2010.11.011. Epub 2010 Dec 18.
To assess adhesion formation and fertility outcome after transient abdominal ovariopexy performed in patients with severe endometriosis.
Retrospective study including 218 patients who underwent surgery for severe endometriosis from 1997 to 2009. One hundred and thirty-nine (64%) patients were infertile. The initial ASRM stage was IV in 139 cases, III in 43 cases and II in 36 cases. Adnexal adhesions were scored by using the Operative Laparoscopy Study Group (OLSG) and modified AFS scoring systems. Unilateral or bilateral transient abdominal ovariopexy of 336 ovaries was performed to prevent adhesion formation or reformation for extensive surgery. In patients who underwent a second operation, adnexal adhesion scores were reported. Fertility outcome was evaluated by a questionnaire.
Second-look surgery was performed after 11.7 ± 2.4 months in 24 patients (11%) who had undergone 38 ovariopexies. Transient abdominal ovariopexy significantly decreased adnexal adhesion scores (p<0.05). Regarding fertility outcome, the median follow up was 19.6 ± 1.5 months. Fifty-eight patients, out of 105 infertile women who actively tried to conceive after surgery, conceived, 21 (36%) spontaneously and 37 (64%) after ART. The median time interval for conception was 8.6 ± 1 months.
In patients with severe endometriosis, transient abdominal ovariopexy is an effective technique in preventing postoperative adhesion formation and in improving fertility outcome.
In 218 patients with severe endometriosis, transient abdominal ovariopexy was an effective technique in preventing adhesion formation and improving fertility outcome.
评估在患有严重子宫内膜异位症的患者中进行短暂性腹部卵巢固定术的粘连形成和生育结局。
回顾性研究包括 218 名于 1997 年至 2009 年因严重子宫内膜异位症接受手术的患者。其中 139 例(64%)患者为不孕。初始 ASRM 分期在 139 例中为 IV 期,在 43 例中为 III 期,在 36 例中为 II 期。采用手术腹腔镜研究组(OLSG)和改良 AFS 评分系统对附件粘连进行评分。对 336 个卵巢进行单侧或双侧短暂性腹部卵巢固定术,以防止广泛手术引起的粘连形成或再形成。在进行第二次手术的患者中,报告了附件粘连评分。通过问卷调查评估生育结局。
在接受了 38 次卵巢固定术的 24 名(11%)患者中,有 24 名患者(11%)在 11.7 ± 2.4 个月后进行了二次手术。短暂性腹部卵巢固定术可显著降低附件粘连评分(p<0.05)。关于生育结局,中位随访时间为 19.6 ± 1.5 个月。在 105 名积极尝试术后怀孕的不孕妇女中,有 58 名怀孕,21 名(36%)自然怀孕,37 名(64%)通过辅助生殖技术(ART)怀孕。怀孕的中位时间间隔为 8.6 ± 1 个月。
在患有严重子宫内膜异位症的患者中,短暂性腹部卵巢固定术是一种预防术后粘连形成和改善生育结局的有效技术。
ART:辅助生殖技术;ASRM:美国生殖医学学会;OLSG:手术腹腔镜研究组;