转移抑制因子与肿瘤微环境。
Metastasis suppressors and the tumor microenvironment.
机构信息
Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Semin Cancer Biol. 2011 Apr;21(2):113-22. doi: 10.1016/j.semcancer.2010.12.005. Epub 2010 Dec 17.
Abstract
The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.
摘要
癌细胞最致命和使人虚弱的特征是其转移的能力。在转移的整个过程中，肿瘤细胞与其他肿瘤细胞、宿主细胞和各种分子相互作用。肿瘤细胞还面临着许多挑战，如血流剪切压力和免疫选择。这篇简短的综述探讨了转移抑制蛋白如何调节肿瘤细胞与肿瘤细胞所处的微环境之间的相互作用。
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