在微重力环境下提高造血前列腺素 D 合酶晶体的质量。
Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment.
机构信息
Confocal Science Inc., Japan.
出版信息
J Synchrotron Radiat. 2011 Jan;18(1):88-91. doi: 10.1107/S0909049510037076. Epub 2010 Nov 5.
Abstract
Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein.
摘要
人造血前腺素合酶是过敏和炎症的较好治疗靶标酶之一，用 22 种抑制剂和在无抑制剂的三种条件下在微重力下进行结晶。大多数在微重力下生长的晶体显示出比在地面上生长的晶体更好的 X 射线衍射图案，表明微重力环境对蛋白质结晶有利，特别是对这种蛋白质而言。
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