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Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy.

作者信息

Gurbel Paul A, Tantry Udaya S

出版信息

Nat Rev Cardiol. 2011 Jan;8(1):7-8. doi: 10.1038/nrcardio.2010.185.

DOI:10.1038/nrcardio.2010.185
PMID:21170003
Abstract
摘要

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Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy.抗血小板治疗：氯吡格雷与质子泵抑制剂的相互作用，仍存争议。
Nat Rev Cardiol. 2011 Jan;8(1):7-8. doi: 10.1038/nrcardio.2010.185.
2
[Controversy regarding the concomitant use of clopidogrel and proton pump inhibitors (PPI)].
Farm Hosp. 2009 Nov-Dec;33(6):339-40. doi: 10.1016/s1130-6343(09)72980-0.
3
Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations.氯吡格雷与质子泵抑制剂：药物相互作用对临床结局的影响及机制解释。
JACC Cardiovasc Interv. 2011 Apr;4(4):365-80. doi: 10.1016/j.jcin.2010.12.009.
4
[Proton pump inhibitors and clopidogrel: a hazardous association?].
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Conn Med. 2010 Jan;74(1):27-31.
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Dtsch Med Wochenschr. 2010 Feb;135(5):203-6. doi: 10.1055/s-0029-1244837. Epub 2010 Jan 26.
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Conflicting evidence surrounding the clopidogrel and proton pump inhibitor drug interaction.关于氯吡格雷与质子泵抑制剂药物相互作用的证据相互矛盾。
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J Pers Med. 2024 May 15;14(5):529. doi: 10.3390/jpm14050529.
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Proton pump inhibitor prescriptions and subsequent use in US veterans diagnosed with gastroesophageal reflux disease.

本文引用的文献

1
Interaction between clopidogrel and proton-pump inhibitors and management strategies in patients with cardiovascular diseases.氯吡格雷与质子泵抑制剂的相互作用及心血管疾病患者的管理策略
Drug Healthc Patient Saf. 2010;2:233-40. doi: 10.2147/DHPS.S7297. Epub 2010 Nov 15.
2
ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents.ACCF/ACG/AHA 2010质子泵抑制剂与噻吩并吡啶类药物联合使用专家共识文件：ACCF/ACG/AHA 2008关于降低抗血小板治疗和非甾体抗炎药使用胃肠道风险专家共识文件的重点更新：美国心脏病学会基金会专家共识文件特别工作组报告
Circulation. 2010 Dec 14;122(24):2619-33. doi: 10.1161/CIR.0b013e318202f701. Epub 2010 Nov 8.
3
质子泵抑制剂处方及其在美国被诊断为胃食管反流病的退伍军人中的后续使用。
J Gen Intern Med. 2013 Jul;28(7):930-7. doi: 10.1007/s11606-013-2345-0.
4
Drug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteers.雷贝拉唑和氯吡格雷在健康中国志愿者中的药物相互作用。
Eur J Clin Pharmacol. 2013 Feb;69(2):179-87. doi: 10.1007/s00228-012-1329-z. Epub 2012 Jun 16.
5
The clinical relevance of the clopidogrel-proton pump inhibitor interaction.氯吡格雷-质子泵抑制剂相互作用的临床相关性。
J Cardiovasc Transl Res. 2012 Aug;5(4):547-52. doi: 10.1007/s12265-011-9334-7. Epub 2012 Feb 14.
6
Variability in the responsiveness to low-dose aspirin: pharmacological and disease-related mechanisms.低剂量阿司匹林反应性的变异性：药理学和疾病相关机制。
Thrombosis. 2012;2012:376721. doi: 10.1155/2012/376721. Epub 2012 Jan 11.
Clopidogrel with or without omeprazole in coronary artery disease.氯吡格雷联合或不联合奥美拉唑用于冠心病。
N Engl J Med. 2010 Nov 11;363(20):1909-17. doi: 10.1056/NEJMoa1007964. Epub 2010 Oct 6.
4
Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study.质子泵抑制剂与心血管风险增加相关，与氯吡格雷的使用无关：一项全国性队列研究。
Ann Intern Med. 2010 Sep 21;153(6):378-86. doi: 10.7326/0003-4819-153-6-201009210-00005.
5
Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes.不同质子泵抑制剂对氯吡格雷抗血小板作用的影响与 CYP2C19 基因型相关。
Br J Clin Pharmacol. 2010 Sep;70(3):383-92. doi: 10.1111/j.1365-2125.2010.03717.x.
6
Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: the clopidogrel Medco outcomes study.质子泵抑制剂对冠状动脉支架置入术后氯吡格雷疗效的影响：氯吡格雷美可结局研究。
Pharmacotherapy. 2010 Aug;30(8):787-96. doi: 10.1592/phco.30.8.787.