VA North Texas Health Care System, Dallas, TX 75216, USA.
J Cardiovasc Transl Res. 2012 Aug;5(4):547-52. doi: 10.1007/s12265-011-9334-7. Epub 2012 Feb 14.
Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel-proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.
质子泵抑制剂常与氯吡格雷和阿司匹林同时用于经皮冠状动脉介入治疗和/或急性冠状动脉综合征患者，以降低与氯吡格雷使用相关的潜在胃肠道出血风险。在过去几年中，有数据支持和反驳氯吡格雷与质子泵抑制剂相互作用。本综述批判性地考虑了当前的证据，并为医疗保健提供者提供了实用建议。
