Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Asian J Androl. 2011 Mar;13(2):231-5. doi: 10.1038/aja.2010.162. Epub 2010 Dec 20.
Retroperitoneal operations, such as radical prostatectomy, often damage the cavernous nerve, resulting in a high incidence of erectile dysfunction. Although improved nerve-sparing techniques have reduced the incidence of nerve injury, and the administration of phosphodiesterase type 5 inhibitors has revolutionized the treatment of erectile dysfunction, this problem remains a considerable challenge. In recent years, scientists have focused on brain-derived neurotrophic factor and vascular endothelial growth factor in the treatment of cavernous nerve injury in rat models. Results showed that both compounds were capable of enhancing the regeneration of the cavernous nerve and that activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway played a major role in the process.
腹膜后手术，如根治性前列腺切除术，常损伤海绵体神经，导致勃起功能障碍的发生率较高。尽管改进的神经保留技术已经降低了神经损伤的发生率，且磷酸二酯酶 5 抑制剂的应用已经彻底改变了勃起功能障碍的治疗，但这个问题仍然是一个相当大的挑战。近年来，科学家们专注于脑源性神经营养因子和血管内皮生长因子在大鼠模型中海绵体神经损伤中的治疗作用。结果表明，这两种化合物都能够增强海绵体神经的再生，而 Janus 激酶（JAK）/信号转导和转录激活因子（STAT）通路的激活在这一过程中起着主要作用。
