抑郁症是免疫系统功能失调的概念。
The concept of depression as a dysfunction of the immune system.
作者信息
Leonard Brian E
机构信息
Pharmacology Department, National University of Ireland, Galway and Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.
出版信息
Curr Immunol Rev. 2010 Aug;6(3):205-212. doi: 10.2174/157339510791823835.
Chronic stress, by initiating changes in the hypothalamic-pituitary-adrenal axis and the immune system, acts as a trigger for anxiety and depression. Both experimental and clinical evidence shows that a rise in the concentrations of proinflammatory cytokines and glucocorticoids, as occurs in chronically stressful situations and in depression, contribute to the behavioural changes associated with depression.A defect in serotonergic function is associated with hypercortisolaemia and the increase in proinflammatory cytokines that accompany depression. Glucocorticoids and proinflammatory cytokines enhance the conversion of tryptophan to kynurenine. In addition to the resulting decrease in the synthesis of brain serotonin, this leads to the formation of neurotoxins such as the glutamate agonist quinolinic acid and contributes to the increase in apoptosis of astrocytes, oligodendroglia and neurons.The importance of the inflammation hypothesis of depression lies in raising the possibility that psychotropic drugs that have a central anti-inflammatory action might provide a new generation of antidepressants.
慢性应激通过引发下丘脑 - 垂体 - 肾上腺轴和免疫系统的变化，成为焦虑和抑郁的触发因素。实验和临床证据均表明，促炎细胞因子和糖皮质激素浓度的升高，如在慢性应激状态和抑郁症中出现的情况，会导致与抑郁症相关的行为变化。血清素能功能缺陷与高皮质醇血症以及抑郁症伴随的促炎细胞因子增加有关。糖皮质激素和促炎细胞因子会增强色氨酸向犬尿氨酸的转化。除了导致脑血清素合成减少外，这还会导致神经毒素如谷氨酸激动剂喹啉酸的形成，并促使星形胶质细胞、少突胶质细胞和神经元的凋亡增加。抑郁症炎症假说的重要性在于提出了这样一种可能性，即具有中枢抗炎作用的精神药物可能会提供新一代的抗抑郁药。
Zotero 插件