Institute of Physiology and Centre of Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
J Nephrol. 2010 Nov-Dec;23 Suppl 16:S145-51.
In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1.
在哺乳动物的肾脏中，过滤后的磷酸盐离子（Pi）沿着近端小管被重吸收。磷酸盐的细胞间转运是由几个位于顶端的、依赖钠离子的 Pi 协同转运蛋白（Na/Pi-cotransporters）启动的，这些转运蛋白属于 SLC 20（SLC20A2）和 34（SLC34A1、SLC34A3）家族。这些 Na/Pi-cotransporters 的顶端丰度通过许多激素/磷酸肽和代谢因子进行调节，以根据身体需要调整肾脏 Pi 重吸收的程度。Pi 重吸收的急性激素调节主要通过调节 SLC34A1（NaPi-IIa）与 PDZ 蛋白 NHERF1 的相互作用来改变 NaPi-IIa 的丰度来实现。
