Knight V, Gilbert B E
Center for Biotechnology, Baylor College of Medicine, Woodlands, Texas 77381.
Lung. 1990;168 Suppl:406-13. doi: 10.1007/BF02718158.
We have described a reasonably accurate method of predicting ribavirin small-particle aerosol dosage administered by nasal inhalation or endotracheal tube adjusted for age, sex, weight, and fever. Regional distribution of inhaled small particles was also presented according to age. This methodology will predict dosage for many other drugs given in this way as long as they are water-soluble and their density in solution does not differ materially from unity. A standardized method of estimating dosage should make possible quantitative comparisons of treatment in different studies. Also presented were studies in which triple the usual dose of ribavirin aerosol was administered, but in one third of the usual dosage period. Aged patients with chronic obstructive pulmonary disease tolerated the treatment with little difficulty, and a group of infants and children with RSV disease recovered promptly with no evidence of intolerance to the treatment. This modification of dosage offers increased accessibility for patient care, and the therapeutic benefits seem as good as the longer regimen. Higher respiratory secretion concentrations with the high-dose regimen may conceivably improve therapeutic results over current methods.
我们已经描述了一种相当准确的方法，用于预测通过鼻吸入或气管内导管给予的利巴韦林小颗粒气雾剂剂量，并根据年龄、性别、体重和发热情况进行调整。还根据年龄呈现了吸入小颗粒的区域分布。只要这些药物是水溶性的，并且它们在溶液中的密度与单位密度没有实质性差异，这种方法就可以预测许多以这种方式给予的其他药物的剂量。一种标准化的剂量估计方法应该能够对不同研究中的治疗进行定量比较。还介绍了一些研究，其中给予的利巴韦林气雾剂剂量是通常剂量的三倍，但给药时间为通常剂量期的三分之一。老年慢性阻塞性肺疾病患者耐受治疗几乎没有困难，一组患有呼吸道合胞病毒疾病的婴幼儿迅速康复，没有对治疗不耐受的迹象。这种剂量调整为患者护理提供了更高的可及性，并且治疗效果似乎与较长疗程一样好。高剂量方案导致的呼吸道分泌物浓度升高可能会比目前的方法改善治疗效果。
