Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Expert Rev Anti Infect Ther. 2011 Jan;9(1):71-9. doi: 10.1586/eri.10.154.
Sepsis is a clinical syndrome defined by physiologic changes indicative of systemic inflammation, which are likely attributable to documented or suspected infection. Septic shock is the progression of those physiologic changes to the extent that delivery of oxygen and metabolic substrate to tissues is compromised. Biomarkers have the potential to diagnose, monitor, stratify and predict outcome in these syndromes. C-reactive protein is elevated in inflammatory and infectious conditions and has long been used as a biomarker indicating infection. Procalcitonin has more recently been shown to better distinguish infection from inflammation. Newer candidate biomarkers for infection include IL-18 and CD64. Lactate facilitates the diagnosis of septic shock and the monitoring of its progression. Multiple stratification biomarkers based on genome-wide expression profiling are under active investigation and present exciting future possibilities.
败血症是一种临床综合征，其特征为生理变化表明全身炎症，这可能归因于已记录或疑似的感染。败血症性休克是这些生理变化进展到组织供氧和代谢底物输送受损的程度。生物标志物有可能在这些综合征中进行诊断、监测、分层和预测结果。C-反应蛋白在炎症和感染情况下升高，长期以来一直被用作指示感染的生物标志物。降钙素原最近已被证明能更好地区分感染和炎症。感染的新候选生物标志物包括白细胞介素-18 和 CD64。乳酸有助于败血症性休克的诊断和其进展的监测。基于全基因组表达谱的多种分层生物标志物正在积极研究中，具有令人兴奋的未来可能性。
