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Unraveling the promise and challenges of biomarkers in pediatric sepsis: a commentary on risk estimation of organ dysfunction and immune dysregulation.

作者信息

Remy Kenneth E, Kissoon Niranjan

机构信息

Department of Medicine, Case Western University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA.

Department of Pediatrics, Case Western University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.

出版信息

Pediatr Res. 2025 Mar 17. doi: 10.1038/s41390-025-03983-5.

DOI:10.1038/s41390-025-03983-5
PMID:40097826
Abstract
摘要

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本文引用的文献

1
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Pediatr Res. 2024 Jun 4. doi: 10.1038/s41390-024-03289-y.
2
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock.《儿童脓毒症和脓毒性休克的 Phoenix 标准的制定与验证》。
JAMA. 2024 Feb 27;331(8):675-686. doi: 10.1001/jama.2024.0196.
3
International Consensus Criteria for Pediatric Sepsis and Septic Shock.国际儿童脓毒症和脓毒性休克共识标准。
JAMA. 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179.
4
Multilevel omics for the discovery of biomarkers in pediatric sepsis.用于发现儿童脓毒症生物标志物的多组学研究
Pediatr Investig. 2023 Nov 21;7(4):277-289. doi: 10.1002/ped4.12405. eCollection 2023 Dec.
5
Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock.内皮功能障碍生物标志物在脓毒症相关急性肾损伤中的预后和预测价值：来自儿科脓毒性休克前瞻性观察队列的风险分层分析。
Crit Care. 2023 Jul 3;27(1):260. doi: 10.1186/s13054-023-04554-y.
6
Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce.在全球范围内使脓毒症的适当定义发挥作用：小儿脓毒症定义工作组的考虑因素。
Pediatr Crit Care Med. 2023 Jun 1;24(6):e263-e271. doi: 10.1097/PCC.0000000000003263. Epub 2023 Apr 25.
7
The evolving value of older biomarkers in the clinical diagnosis of pediatric sepsis.在儿科脓毒症的临床诊断中，不断演变的旧生物标志物的价值。
Pediatr Res. 2023 Mar;93(4):789-796. doi: 10.1038/s41390-022-02190-w. Epub 2022 Aug 4.
8
Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation.用于估计儿科感染性休克存活后医院死亡率和长期生活质量发病率风险的生物标志物：儿科脓毒症后评估研究的二次分析。
Pediatr Crit Care Med. 2021 Jan 1;22(1):8-15. doi: 10.1097/PCC.0000000000002572.
9
Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study.全球、地区和国家脓毒症发病率和死亡率，1990-2017 年：全球疾病负担研究分析。
Lancet. 2020 Jan 18;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7.
10
The Pediatric Sepsis Biomarker Risk Model (PERSEVERE) Biomarkers Predict Clinical Deterioration and Mortality in Immunocompromised Children Evaluated for Infection.儿科脓毒症生物标志物风险模型（PERSEVERE）生物标志物可预测感染评估免疫功能低下儿童的临床恶化和死亡率。
Sci Rep. 2019 Jan 23;9(1):424. doi: 10.1038/s41598-018-36743-z.