在芬兰患者中分离出的空肠弯曲菌根据感染来源而有所不同。
Campylobacter jejuni isolates in Finnish patients differ according to the origin of infection.
机构信息
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, PO Box 21, FIN-00014, Helsinki, Finland.
出版信息
Gut Pathog. 2010 Dec 20;2(1):22. doi: 10.1186/1757-4749-2-22.
BACKGROUND
Campylobacter jejuni is a significant cause of bacterial enteritis worldwide. Very little is known about the pathogenicity mechanisms and virulence factors of this important enteropathogen. C. jejuni isolates from 166 Finnish patients, collected from July to December in 2006, were studied for the presence of putative virulence factors and susceptibility to antimicrobials. Isolates were tested for production of γ-glutamyltransferase (GGT) as well as the presence of genes ceuE, cgtB, ciaB, cj0486, pldA, virB11, wlaN, and the gene cluster cdtABC. Bacterial characteristics were compared to information on foreign travel history as well as information on the course and the symptoms of disease obtained from questionnaires returned by patients.
RESULTS
Except for one domestic isolate, antimicrobial resistance was only detected in isolates of foreign origin. Univariate analyses showed association between bloody stools and both GGT production (p = 0.025) and the presence of cgtB (p = 0.034). Multivariate analysis verified that GGT production was more prevalent in domestic isolates (p < 0.0001), while the genes cj0486 (p < 0.0001) and ceuE (p < 0.0001) were associated with C. jejuni isolates of foreign origin.
CONCLUSIONS
The results indicate that imported and domestic C. jejuni isolates differ significantly in several aspects from each other.
背景
空肠弯曲菌是全球范围内细菌性肠炎的重要致病菌。目前对于这种重要肠道病原体的致病机制和毒力因子知之甚少。本研究对 2006 年 7 月至 12 月采集的 166 例芬兰患者的空肠弯曲菌分离株进行了研究，以了解其潜在的毒力因子和药敏情况。检测了这些分离株 γ-谷氨酰转移酶（GGT）的产生情况以及 ceuE、cgtB、ciaB、cj0486、pldA、virB11、wlaN 等基因和 cdtABC 基因簇的存在情况。对细菌特征与来自患者的旅行史、疾病病程和症状等问卷调查信息进行了比较。
结果
除了一个国内分离株，仅在国外来源的分离株中检测到了抗生素耐药性。单因素分析显示，血便与 GGT 产生（p = 0.025）和 cgtB 存在（p = 0.034）之间存在关联。多因素分析证实，GGT 产生在国内分离株中更为常见（p < 0.0001），而 cj0486（p < 0.0001）和 ceuE（p < 0.0001）基因则与国外来源的空肠弯曲菌分离株有关。
结论
结果表明，进口和国产空肠弯曲菌分离株在多个方面存在显著差异。
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