Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
J Crohns Colitis. 2008 Jun;2(2):131-41. doi: 10.1016/j.crohns.2007.10.006. Epub 2007 Dec 21.
Because of the changing epidemiology of Inflammatory Bowel Diseases (IBD), we set out to characterize the population-based prevalence of Crohn's Disease (CD) and Ulcerative Colitis (UC) in a defined population of Switzerland.
Adult IBD patients were identified by a cross-matched review of histological, hospital and gastroenterologist files throughout a geographical defined population (Canton of Vaud). Demographic factors statistically significantly associated with prevalence were evaluated using a stepwise Poisson regression analysis. Results were compared to IBD prevalence rates in other population-based studies and time trends were performed, based on a systematic literature review.
Age and sex-adjusted prevalence rates were 205.7 IBD (100.7 CD and 105.0 UC) cases per 10(5) inhabitants. Among 1016 IBD patients (519 CD and 497 UC), females outnumbered males in CD (p<0.001), but males were more represented in elderly UC patients (p=0.008). Thus, being a male was statistically associated with UC (Relative Risk (RR) 1.25; p=0.013), whereas being a female was associated with CD (RR 1.27; p=0.007). Living in an urban zone was associated with both CD and UC (RR 1.49; p<0.001, 1.63; p<0.001, respectively). From 1960 to 2005, increases in UC and CD prevalences of 2.4% (95%CI, 2.1%-2.8%; p<0.001) and 3.6% (95%CI, 3.1%-4.1%; p<0.001) per annum were found in industrialised countries.
Extrapolating our data to all of Switzerland yields an estimate of 12,000 IBD cases for the country, or 1 in 500 inhabitants. Our study gives support to an increase in IBD prevalence in Europe.
由于炎症性肠病（IBD）的流行病学变化，我们着手描述在瑞士一个特定人群中基于人群的克罗恩病（CD）和溃疡性结肠炎（UC）的患病率。
通过对整个地理定义人群（沃州）的组织学、医院和胃肠病学家档案进行交叉匹配审查，确定成人 IBD 患者。使用逐步泊松回归分析评估与患病率统计学显著相关的人口统计学因素。将结果与其他基于人群的研究中的 IBD 患病率进行比较，并根据系统文献综述进行时间趋势分析。
年龄和性别调整后的患病率为每 105 居民中有 205.7 例 IBD（100.7 例 CD 和 105.0 例 UC）。在 1016 例 IBD 患者（519 例 CD 和 497 例 UC）中，女性在 CD 中多于男性（p<0.001），但在老年 UC 患者中男性更为多见（p=0.008）。因此，男性在统计学上与 UC 相关（相对风险（RR）1.25；p=0.013），而女性与 CD 相关（RR 1.27；p=0.007）。居住在城市地区与 CD 和 UC 均相关（RR 1.49；p<0.001，1.63；p<0.001）。从 1960 年到 2005 年，工业化国家中 UC 和 CD 的患病率每年分别增加 2.4%（95%CI，2.1%-2.8%；p<0.001）和 3.6%（95%CI，3.1%-4.1%；p<0.001）。
将我们的数据外推到瑞士全境，估计该国的 IBD 病例数为 12000 例，即每 500 居民中有 1 例。我们的研究支持欧洲 IBD 患病率的增加。
